ArticleScience signaling2016
Sleep deprivation impairs memory by attenuating mTORC1-dependent protein synthesis.
Article in Science signaling, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
94 citing papers in PubMed, 159 citations in OpenAlex.
- Shank3 mutation disrupts the molecular signature of sleepiness across development.bioRxiv : the preprint server for biology · 2026Article
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- Sleep differentially modulates synaptic vesicle protein 2A and spine density across cortical regions and development.iScience · 2026Article
- Review
- Let's talk about sex: Male and female mice show similar fear memory retention despite hippocampal activity differences during encoding and consolidation.bioRxiv : the preprint server for biology · 2026Article
- Caffeine reverses sleep deprivation-induced synaptic and social memory deficits via adenosine receptor modulation in the male mouse hippocampal CA2 region.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Repeated sleep deprivation selectively reactivates hippocampal CA1 pyramidal neurons.Molecular brain · 2026Article
- METTL3-mediated mTranslational psychiatry · 2026Article
- Does It Matter What Keeps You Awake? Effects of Two Different Sleep Deprivation Methods on Object-Location Memory and Hippocampal c-Fos Expression in Mice.Journal of sleep research · 2026Article
- Cell Type-Specific mTORC1 Signaling and Translational Control in Synaptic Plasticity and Memory.Journal of neurochemistry · 2025Review
- Long non-coding RNA Cerox1 targets components of the mitochondrial electron transport chain to regulate the memory impairment caused by sleep deprivation.Research square · 2025Article
- Microbiota metabolites affect sleep as drivers of brain‑gut communication (Review).International journal of molecular medicine · 2025Review
- Transcriptional dynamics of sleep deprivation and subsequent recovery sleep in the male mouse cortex.Physiological genomics · 2025Article
- Article
- Molecular basis identification and hypnotic drug interactions for cognitive impairment related to sleep deprivation.BMC psychiatry · 2025Article
- Brief sleep disruption alters synaptic structures among hippocampal and neocortical somatostatin-expressing interneurons.bioRxiv : the preprint server for biology · 2025Article
- Exploring β-caryophyllene: a non-psychotropic cannabinoid's potential in mitigating cognitive impairment induced by sleep deprivation.Archives of pharmacal research · 2025Review
- Cold-raising unmasks sleep disruption in amicroPublication biology · 2025Article
- The Overexpression of eIF4E Decreases Oxytocin Levels and Induces Social Cognitive Behavioral Disorders in Mice.eNeuro · 2024Article
- A genome-wide methylation analysis of Chinese Han patients with chronic insomnia disorder.Sleep & breathing = Schlaf & Atmung · 2024Article
34 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
Sleep deprivation is a public health epidemic that causes wide-ranging deleterious consequences, including impaired memory and cognition. Protein synthesis in hippocampal neurons promotes memory and cognition. The kinase complex mammalian target of rapamycin complex 1 (mTORC1) stimulates protein synthesis by phosphorylating and inhibiting the eukaryotic translation initiation factor 4E-binding protein 2 (4EBP2). We investigated the involvement of the mTORC1-4EBP2 axis in the molecular mechanisms mediating the cognitive deficits caused by sleep deprivation in mice. Using an in vivo protein translation assay, we found that loss of sleep impaired protein synthesis in the hippocampus. Five hours of sleep loss attenuated both mTORC1-mediated phosphorylation of 4EBP2 and the interaction between eukaryotic initiation factor 4E (eIF4E) and eIF4G in the hippocampi of sleep-deprived mice. Increasing the abundance of 4EBP2 in hippocampal excitatory neurons before sleep deprivation increased the abundance of phosphorylated 4EBP2, restored the amount of eIF4E-eIF4G interaction and hippocampal protein synthesis to that seen in mice that were not sleep-deprived, and prevented the hippocampus-dependent memory deficits associated with sleep loss. These findings collectively demonstrate that 4EBP2-regulated protein synthesis is a critical mediator of the memory deficits caused by sleep deprivation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.