ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2016
Association of an Index of Healthy Aging With Incident Cardiovascular Disease and Mortality in a Community-Based Sample of Older Adults.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Relationship Between Successful Aging and All-Cause Mortality Risk in Older Adults: A Systematic Review and Meta-Analysis of Cohort Studies.Frontiers in medicine · 2021Pooled it
- How are missing data in covariates handled in observational time-to-event studies in oncology? A systematic review.BMC medical research methodology · 2020Pooled it
- Effect of Diet, Exercise, or Both on Biological Age and Healthy Aging in Older Adults with Obesity: Secondary Analysis of a Randomized Controlled Trial.The journal of nutrition, health & aging · 2022Trial
- Effect of Intentional Weight Loss on Mortality Biomarkers in Older Adults With Obesity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Trial
- A novel clinical biomarker-based Physiology Healthy Aging Index and risk of all-cause and cause-specific mortality: A 20-year prospective cohort study.GeroScience · 2026Article
- Coagulation and Blood Factors and Clinical Disease Indicators in Patients with Chronic Angioedema and Urticaria-A Validation Study.Biomedicines · 2026Article
- Association between long-term healthy aging trajectories and all-cause mortality among middle-aged and older adults.Archives of public health = Archives belges de sante publique · 2025Article
- Association of a healthy ageing index with health-related outcomes in a multi-ethnic cohort from Singapore.BMC geriatrics · 2024Article
- Associations of healthy aging index and all-cause and cause-specific mortality: a prospective cohort study of UK Biobank participants.GeroScience · 2024Article
- The Potential Role of C-Reactive Protein in Metabolic-Dysfunction-Associated Fatty Liver Disease and Aging.Biomedicines · 2023Review
- Associations of Modified Healthy Aging Index With Major Adverse Cardiac Events, Major Coronary Events, and Ischemic Heart Disease.Journal of the American Heart Association · 2023Article
- Predictors of healthy physiological aging across generations in a 30-year population-based cohort study: the Doetinchem Cohort Study.BMC geriatrics · 2023Article
- Construction of healthy aging index from two different datasets.Frontiers in public health · 2023Article
- Hematopoiesis, Inflammation and Aging-The Biological Background and Clinical Impact of Anemia and Increased C-Reactive Protein Levels on Elderly Individuals.Journal of clinical medicine · 2022Review
- High-Sensitivity C-Reactive Protein Relationship with Metabolic Disorders and Cardiovascular Diseases Risk Factors.Life (Basel, Switzerland) · 2021Article
- Domains and Measurements of Healthy Aging in Epidemiological Studies: A Review.The Gerontologist · 2019Review
- Mortality in Relation to Changes in a Healthy Aging Index: The Health, Aging, and Body Composition Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup.GeroScience · 2018Review
- A Modified Healthy Aging Index and Its Association with Mortality: The National Health and Nutrition Examination Survey, 1999-2002.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundThe healthy aging index (HAI) was developed as a marker of health in multiple systems that can identify individuals who age most successfully.
methodsWe calculated an HAI in 934 Framingham Offspring Study participants aged 60 or older at baseline. Heart rate and C-reactive protein (CRP) were added in modified versions of the HAI. Cox proportional hazard models were used to quantify the association of the HAI with mortality, cardiovascular disease (CVD), and cancer. We used fully conditional specification to multiply impute missing values for HAI components, increasing the sample size by 44%.
resultsOver 10 years of follow-up, there were 138 deaths, 103 incident cases of CVD, and 138 incident cases of cancer. In models adjusted for age, sex, and behavioral risk factors, the HAI was associated with mortality (hazard ratio [HR] per unit of HAI 1.24, 95% confidence interval [CI] 1.13-1.36) and with CVD (HR 1.27, 95% CI 1.13-1.42), but not with cancer (HR 1.01, 95% CI 0.91-1.11) in observed (non-missing) data. In multivariable models further adjusting for prevalent diseases, results were slightly attenuated. When including heart rate and CRP, a modified HAI gave stronger associations. Results with imputed data are similar to results from complete case analyses.
conclusionsIn our large community-based sample, the HAI is a strong predictor of mortality and CVD. Other factors that are strongly associated with mortality, such as heart rate and CRP can improve the ability of the HAI to identify the healthiest older adults.
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