Evidence map›Paper›PMID 27116971›Full record

ReviewWorld journal of microbiology & biotechnology2016

Updates on industrial production of amino acids using Corynebacterium glutamicum.

Volker F Wendisch, João M P Jorge, Fernando Pérez-García, Elvira Sgobba

Abstract readReview
PubMed Publisher
In one paragraph

Review in World journal of microbiology & biotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed.

  1. Growth ofApplied and environmental microbiology · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Enhancement Strategy for Protocatechuic Acid Production UsingInternational journal of molecular sciences · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Probiotics in Postoperative Pain Management.Journal of personalized medicine · 2023
    Review
  12. Article
  13. Article
  14. C-di-AMP Is a Second Messenger inMicroorganisms · 2023
    Article
  15. Synthetic biology tools for engineeringComputational and structural biotechnology journal · 2023
    Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. The Role of the Human Microbiome in the Pathogenesis of Pain.International journal of molecular sciences · 2022
    Review

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Volker F WendischGenetics of Prokaryotes, Faculty of Biology and Center for Biotechnology (CeBiTec), Bielefeld University, Universitätsstraße 25, 33615, Bielefeld, Germany. volker.wendisch@uni-bielefeld.de.
João M P JorgeGenetics of Prokaryotes, Faculty of Biology and Center for Biotechnology (CeBiTec), Bielefeld University, Universitätsstraße 25, 33615, Bielefeld, Germany.
Fernando Pérez-GarcíaGenetics of Prokaryotes, Faculty of Biology and Center for Biotechnology (CeBiTec), Bielefeld University, Universitätsstraße 25, 33615, Bielefeld, Germany.
Elvira SgobbaGenetics of Prokaryotes, Faculty of Biology and Center for Biotechnology (CeBiTec), Bielefeld University, Universitätsstraße 25, 33615, Bielefeld, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

L-Amino acids find various applications in biotechnology. L-Glutamic acid and its salts are used as flavor enhancers. Other L-amino acids are used as food or feed additives, in parenteral nutrition or as building blocks for the chemical and pharmaceutical industries. L-amino acids are synthesized from precursors of central carbon metabolism. Based on the knowledge of the biochemical pathways microbial fermentation processes of food, feed and pharma amino acids have been developed. Production strains of Corynebacterium glutamicum, which has been used safely for more than 50 years in food biotechnology, and Escherichia coli are constantly improved using metabolic engineering approaches. Research towards new processes is ongoing. Fermentative production of L-amino acids in the million-ton-scale has shaped modern biotechnology and its markets continue to grow steadily. This review focusses on recent achievements in strain development for amino acid production including the use of CRISPRi/dCas9, genome-reduced strains, biosensors and synthetic pathways to enable utilization of alternative carbon sources.

Indexed as

Amino AcidsBiotechnologyCorynebacterium glutamicumIndustrial MicrobiologyMetabolic EngineeringAmino AcidsBiosensorsCRISPRi-dCas9Flexible feedstock conceptGABAGenome-reduced strainsL-ArginineL-CitrullineL-GlutamateL-LysineL-OrnithineL-Proline

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.