Evidence map›Paper›PMID 27116682›Full record

Trial reportJournal of neural transmission (Vienna, Austria : 1996)2016

Preliminary investigation of the effects of γ-tACS on working memory in schizophrenia.

Kate E Hoy, Dean Whitty, Neil Bailey, Paul B Fitzgerald

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of neural transmission (Vienna, Austria : 1996), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06547996 (Effects of Transcranial Electrical Stimulation Combined With Retrieval Practice on Semantic Memory in Patients With Schizophrenia), which is not on this map. Cited by 28 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06547996 nacompletednot on this mapstarted 2024, after this paper: background citation

Effects of Transcranial Electrical Stimulation Combined With Retrieval Practice on Semantic Memory in Patients With Schizophrenia

TypeinterventionalSponsorNortheast Normal UniversityRan2024 to 2024Enrolled72ConditionsSchizophrenic PatientsArmstES-tDCS group, tES-tACS group, tES-sham group
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  5. Pooled it
  6. Trial
  7. Review
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  14. Causal functional maps of brain rhythms in working memory.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Review
  16. Transcranial Alternating Current Stimulation (tACS) and Its Role in Schizophrenia: A Scoping Review.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023
    Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kate E HoyMonash Alfred Psychiatry Research Centre, The Alfred and Monash University, Central Clinical School, Melbourne, VIC, Australia. kate.hoy@monash.edu.
Dean WhittyMonash Alfred Psychiatry Research Centre, The Alfred and Monash University, Central Clinical School, Melbourne, VIC, Australia.
Neil BaileyMonash Alfred Psychiatry Research Centre, The Alfred and Monash University, Central Clinical School, Melbourne, VIC, Australia.
Paul B FitzgeraldMonash Alfred Psychiatry Research Centre, The Alfred and Monash University, Central Clinical School, Melbourne, VIC, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Working memory impairment in schizophrenia has been strongly associated with abnormalities in gamma oscillations within the dorsolateral prefrontal cortex (DLFPC). We recently published the first ever study showing that anodal transcranial direct current stimulation (tDCS) to the left DLPFC was able to significantly improve working memory in schizophrenia and did so seemingly via restoring normal gamma oscillatory function. Transcranial alternating current stimulation (tACS) is a form of electrical brain stimulation that delivers stimulation at a specific frequency and has been shown to entrain endogenous cortical oscillations. Therefore, gamma (γ) tACS may be even more effective than tDCS in improving working memory in schizophrenia. In a randomized repeated-measures study we compared the effects of γ-tACS, tDCS and sham stimulation on the performance of the two back working memory tasks in ten patients with schizophrenia. There was a significant time by stimulation interaction, with tDCS and sham showing trend-level improvements in working memory, while γ-tACS, contrary to our hypothesis, showed no change. The results are discussed in light of posited divergent effects of tACS and tDCS on the pathophysiology of working memory impairment in schizophrenia.

Indexed as

AdultAnalysis of VarianceFemaleHumansMaleMemory DisordersMemory, Short-TermMiddle AgedNeuropsychological TestsPsychiatric Status Rating ScalesReaction TimeSchizophreniaSingle-Blind MethodTranscranial Direct Current StimulationTranscranial Magnetic StimulationGammaSchizophreniatACSWorking memory

Identifiers

PMID27116682

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.