ArticlePloS one2016
Temporal Changes in Local Functional Connectivity Density Reflect the Temporal Variability of the Amplitude of Low Frequency Fluctuations in Gray Matter.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Mind-body exercise improves cognitive function and modulates the function and structure of the hippocampus and anterior cingulate cortex in patients with mild cognitive impairment.NeuroImage. Clinical · 2019Trial
- Altered Temporospatial Variability of Dynamic Amplitude of Low-Frequency Fluctuation in Children with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2026Article
- Brain asymmetry and its association with inattention and heritability during neurodevelopment.Translational psychiatry · 2025Article
- Resting state BOLD-perfusion coupling patterns using multiband multi-echo pseudo-continuous arterial spin label imaging.Scientific reports · 2025Article
- Examining the role of dopamine in methylphenidate's effects on resting brain function.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Dynamic alterations in the amplitude of low-frequency fluctuation in patients with cerebral small vessel disease.Frontiers in molecular neuroscience · 2023Article
- Cortical D1 and D2 dopamine receptor availability modulate methylphenidate-induced changes in brain activity and functional connectivity.Communications biology · 2022Article
- Divergent time-varying connectivity of thalamic sub-regions characterizes clinical phenotypes and cognitive status in multiple sclerosis.Molecular psychiatry · 2022Article
- Acupuncture modulates the frequency-specific functional connectivity density in primary dysmenorrhea.Frontiers in neuroscience · 2022Article
- Implementation of Imaging Methods in Evaluation of T2DM-Correlated Brain Alterations and Cognitive Dysfunction.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2020Review
- Overcoming randomness does not rule out the importance of inherent randomness for functionality.Journal of biosciences · 2019Review
- Association Between Brain Activation and Functional Connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- A Reduction in Video Gaming Time Produced a Decrease in Brain Activity.Frontiers in human neuroscience · 2019Article
- Neural and metabolic basis of dynamic resting state fMRI.NeuroImage · 2018Review
- PAGANI Toolkit: Parallel graph-theoretical analysis package for brain network big data.Human brain mapping · 2018Article
- Neuroscience Information Toolbox: An Open Source Toolbox for EEG-fMRI Multimodal Fusion Analysis.Frontiers in neuroinformatics · 2018Article
- Distinction Between Variability-Based Modulation and Mean-Based Activation Revealed by BOLD-fMRI and Eyes-Open/Eyes-Closed Contrast.Frontiers in neuroscience · 2018Article
- Abnormal Functional Connectivity Density in Amyotrophic Lateral Sclerosis.Frontiers in aging neuroscience · 2018Article
- Temporal Evolution of Brain Functional Connectivity Metrics: Could 7 Min of Rest be Enough?Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Task-Related Modulations of BOLD Low-Frequency Fluctuations within the Default Mode Network.Frontiers in physics · 2017Article
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Authors and funding
3 authors.
Funding
Abstract
Data-driven functional connectivity density (FCD) mapping is being increasingly utilized to assess brain connectomics at rest in the healthy brain and its disruption in neuropsychiatric diseases with the underlying assumption that the spatiotemporal hub distribution is stationary. However, recent studies show that functional connectivity is highly dynamic. Here we study the temporal variability of the local FCD (lFCD) at high spatiotemporal resolution (2-mm isotropic; 0.72s) using a sliding-window approach and 'resting-state' datasets from 40 healthy subjects collected under the Human Connectome Project. Prominent functional connectivity hubs in visual and posterior parietal cortices had pronounced temporal changes in local FCD. These dynamic patterns in the strength of the lFCD hubs occurred in cortical gray matter with high sensitivity (up to 85%) and specificity (> 85%) and showed high reproducibility (up to 72%) across sessions and high test-retest reliability (ICC(3,1) > 0.5). The temporal changes in lFCD predominantly occurred in medial occipitoparietal regions and were proportional to the strength of the connectivity hubs. The temporal variability of the lFCD was associated with the amplitude of the low frequency fluctuations (ALFF). Pure randomness did not account for the probability distribution of lFCD. Shannon entropy increased in proportion to the strength of the lFCD hubs suggesting high average flow of information per unit of time in the lFCD hubs, particularly in medial occipitoparietal regions. Thus, the higher dynamic range of the lFCD hubs is consistent with their role in the complex orchestration of interacting brain networks.
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