ArticlePloS one2016
Multigenerational Effects of Heavy Metals on Feeding, Growth, Initial Reproduction and Antioxidants in Caenorhabditis elegans.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 54 citations in OpenAlex.
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- Genotoxicity and acute toxicity of Hyunburikyung-tang: assessing the safety of prescribing traditional Korean medicine for dysmenorrhea.BMC complementary medicine and therapies · 2025Article
- Assessment of azithromycin-induced toxicity inToxicology reports · 2024Article
- The intertwining between lead and ethanol in the model organismFrontiers in toxicology · 2022Review
- Transgenerational effects in DNA methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure.Scientific reports · 2021Article
- Circular Estimate Method (CEM) - a Simple Method to EstimateBiological procedures online · 2019Article
- Transgenerational interactions between pesticide exposure and warming in a vector mosquito.Evolutionary applications · 2018Article
- Superoxide Dismutase (SOD) and Catalase (CAT) Activity Assay Protocols forBio-protocol · 2017Article
- Multigenerational effects of copper nanomaterials (CuONMs) are different of those of CuClScientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Earlier studies showed that toxicities of excessive metals lasted over generations. Yet, these studies mainly employed one-generation exposure, and the effects of multigenerational challenges need further studies. Presently, Caenorhabditis elegans were exposed to cadmium, copper, lead and zinc for four consecutive generations (G1 to G4) at environmental concentrations. The feeding, growth, initial reproduction, superoxide dismutase (SOD) and catalase (CAT) were determined. All data were represented in the percentage of that in control (POC), and POC in the control was normalized to 100%. In G1 and G2, the POC values in feeding, growth and initial reproduction were generally within 10% of the control (100%), indicating non-significant effects. The POC values in SOD and CAT were significantly higher than 100%, showing stimulatory effects. In G3 and G4, the POC values in feeding, growth and initial reproduction were significantly lower than 100%, showing inhibitory effects which were more severe in G4 than in G3. Meanwhile, SOD and CAT continuously showed stimulatory effects, and the stimulatory effects on SOD increased from G1 to G4. The effects with multigenerational challenges were different from those in one-generation exposure. The effects in later generations demonstrated the importance of multigenerational challenges in judging long-term influences of metals.
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Registered trials
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