ArticleJournal of acquired immune deficiency syndromes (1999)2016
Higher Time-Updated Body Mass Index: Association With Improved CD4+ Cell Recovery on HIV Treatment.
Article in Journal of acquired immune deficiency syndromes (1999), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Gender differences for frailty in HIV-infected patients on stable antiretroviral therapy and with an undetectable viral load.PloS one · 2019Trial
- Article
- The Body Fat Percentage Rather Than the BMI Is Associated with the CD4 Count among HIV Positive Japanese Individuals.Nutrients · 2022Article
- Construction and validation of a prognostic nomogram for predicting the survival of HIV/AIDS adults who received antiretroviral therapy: a cohort between 2003 and 2019 in Nanjing.BMC public health · 2022Article
- Association of body mass index with immune recovery, virological failure and cardiovascular disease risk among people living with HIV.HIV medicine · 2021Article
- Undernutrition and HIV Infection in Sub-Saharan Africa: Health Outcomes and Therapeutic Interventions.Current HIV/AIDS reports · 2021Review
- Leptin Promotes Greater Ki67 Expression in CD4Frontiers in immunology · 2021Article
- Contribution of Adipose Tissue to the Chronic Immune Activation and Inflammation Associated With HIV Infection and Its Treatment.Frontiers in immunology · 2021Review
- Incomplete immune reconstitution in HIV/AIDS patients on antiretroviral therapy: Challenges of immunological non-responders.Journal of leukocyte biology · 2020Review
- The Impact of microRNA Regulation on Immune Recovery in HIV-1-Infected Patients Treated during Acute Infection: A Pilot Study.BioMed research international · 2020Article
- Impact of Genetic and Nongenetic Factors on Body Mass Index and Waist-Hip Ratio Change in HIV-Infected Individuals Initiating Antiretroviral Therapy.Open forum infectious diseases · 2020Article
- Predictive effects of body mass index on immune reconstitution among HIV-infected HAART users in China.BMC infectious diseases · 2019Article
- Brief Report: Circulating Markers of Immunologic Activity Reflect Adiposity in Persons With HIV on Antiretroviral Therapy.Journal of acquired immune deficiency syndromes (1999) · 2018Article
- Article
- A retrospective cohort study of body mass index and survival in HIV infected patients with and without TB co-infection.Infectious diseases of poverty · 2018Article
- HIV and Obesity Comorbidity Increase Interleukin 6 but Not Soluble CD14 or D-Dimer.Journal of acquired immune deficiency syndromes (1999) · 2017Observational
- Higher Body Mass Index Is Associated With Greater Proportions of Effector CD8+ T Cells Expressing CD57 in Women Living With HIV.Journal of acquired immune deficiency syndromes (1999) · 2017Article
- Hookworm infection is associated with decreased CD4+ T cell counts in HIV-infected adult Ugandans.PLoS neglected tropical diseases · 2017Article
- Sex disparities in outcomes among adults on long-term antiretroviral treatment in northern Nigeria.International health · 2017Article
- Trends in Nonlipid Cardiovascular Disease Risk Factor Management in the Women's Interagency HIV Study and Association with Adherence to Antiretroviral Therapy.AIDS patient care and STDs · 2016Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
backgroundPrior studies found overweight or obese HIV-infected individuals had greater early CD4 cell recovery on antiretroviral therapy (ART), but the results have been inconsistent. We assessed the longitudinal relationship between body mass index (BMI) and CD4 cell recovery on ART in a large, multisite cohort to identify potential physiologic links between adiposity and CD4 cell expansion.
methodsWe modeled the relationship of time-updated BMI with CD4 count in patients starting ART from 17 North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) cohorts. The primary analysis used a linear mixed effects model incorporating up to 13 years of data per patient and adjusted for age, sex, race, ART regimen, baseline CD4 count and other covariates. Sensitivity analyses limited the cohort to patients with sustained viral suppression or censored at virologic failure.
resultsFourteen thousand eighty-four HIV-infected individuals initiating ART contributed data between 1998 and 2010. Time-updated BMI was significantly associated with CD4 cell recovery over time (P < 0.001). After 5 years of ART, the mean CD4 count at a BMI of 30 kg/m was 22% higher than at a BMI of 22 kg/m (606 vs. 498 cells per microliter) and 34% higher at a BMI of 40 kg/m (665 vs. 498 cells per microliter). Results were similar in the sensitivity analyses. DISCUSSION: Higher BMI is associated with long-term advantages in immune recovery on ART. Although it is unclear if this impacts health outcomes, including balancing the negative health effects of obesity, elucidating the underlying mechanism could identify therapies for patients with suboptimal immune reconstitution.
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