Evidence map›Paper›PMID 27115600›Full record

ArticleChannels (Austin, Tex.)2016

Similar molecular determinants on Rem mediate two distinct modes of inhibition of Ca

Akil A Puckerin, Donald D Chang, Prakash Subramanyam, Henry M Colecraft

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Channels (Austin, Tex.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Inhibitory effects on L- and N-type calcium channels by a novel CaNaunyn-Schmiedeberg's archives of pharmacology · 2022
    Article
  3. Review
  4. The life cycle of voltage-gated CaNeuronal signaling · 2021
    Review
  5. Review
  6. Review
  7. Engineering selectivity into RGK GTPase inhibition of voltage-dependent calcium channels.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  8. CaHeart rhythm · 2018
    Review
  9. Defining the MO's of RGK proteins.Channels (Austin, Tex.) · 2016
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Akil A Puckerina Department of Pharmacology & Molecular Signaling , Columbia University , New York , NY , USA.
Donald D Changb Department of Physiology & Cellular Biophysics , Columbia University , New York , NY , USA.
Prakash Subramanyamb Department of Physiology & Cellular Biophysics , Columbia University , New York , NY , USA.
Henry M Colecrafta Department of Pharmacology & Molecular Signaling , Columbia University , New York , NY , USA.
Columbia University · US

Funding

Small G-protein Regulation of Calcium ChannelsR01GM107585 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI COLECRAFT, HENRY M. · 2014 to 2017
$1.2M
NIGMS NIH HHS R01 GM107585
6 · The paper itself

Abstract

Rad/Rem/Rem2/Gem (RGK) proteins are Ras-like GTPases that potently inhibit all high-voltage-gated calcium (Ca

Indexed as

AnimalsCalcium Channels, L-TypeCells, CulturedHeart VentriclesHEK293 CellsHumansMaleMonomeric GTP-Binding ProteinsMyocytes, CardiacRats, Sprague-DawleyCalcium Channels, L-TypeGEM protein, humanL-type calcium channel alpha(1C)Monomeric GTP-Binding ProteinsRem protein, mouseCaV1.2GemL-type calcium channelRemRGK protein

Identifiers

PMID27115600
PMCPMC4988437
OpenAlexW2342836641

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.