Evidence map›Paper›PMID 27115557›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2016

Tunable Thermal-Sensitive Polymer-Graphene Oxide Composite for Efficient Capture and Release of Viable Circulating Tumor Cells.

Hyeun Joong Yoon, Apoorv Shanker, Yang Wang, Molly Kozminsky, Qu Jin, Nallasivam Palanisamy, Monika L Burness, Ebrahim Azizi, Diane M Simeone, Max S Wicha and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 150 citations in OpenAlex.

  1. Circulating Tumor Cells: Emerging Frontiers in Cancer Technology.Expert reviews in molecular medicine · 2026
    Review
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  12. Recent advances in 2D material-based phototherapy.Frontiers in bioengineering and biotechnology · 2023
    Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Application of Microfluidics in Detection of Circulating Tumor Cells.Frontiers in bioengineering and biotechnology · 2022
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Hyeun Joong YoonDepartment of Chemical Engineering, University of Michigan, 2300 Hayward Street, Ann Arbor, MI 48109, USA.
Apoorv ShankerBiointerfaces Institute, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI 48109, USA.
Yang WangDepartment of Chemical Engineering, University of Michigan, 2300 Hayward Street, Ann Arbor, MI 48109, USA.
Molly KozminskyDepartment of Chemical Engineering, University of Michigan, 2300 Hayward Street, Ann Arbor, MI 48109, USA.
Qu JinDepartment of Chemical Engineering, University of Michigan, 2300 Hayward Street, Ann Arbor, MI 48109, USA.
Nallasivam PalanisamyHenry Ford Health System, 1 Ford Place, Detroit, MI 48202, USA.
Monika L BurnessDepartment of Internal Medicine, University of Michigan Comprehensive Cancer Center, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA.
Ebrahim AziziDepartment of Internal Medicine, University of Michigan Comprehensive Cancer Center, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA.
Diane M SimeoneTranslational Oncology Program, University of Michigan Health System, 1600 Huron Pkwy, Ann Arbor, MI 48109, USA.
Max S WichaBiointerfaces Institute, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI 48109, USA.
Jinsang KimDepartment of Chemical Engineering, University of Michigan, 2300 Hayward Street, Ann Arbor, MI 48109, USA.
Sunitha NagrathDepartment of Chemical Engineering, University of Michigan, 2300 Hayward Street, Ann Arbor, MI 48109, USA.
University of Michigan–Ann Arbor · USMichigan Medicine · USBioSurfaces (United States) · USMichigan Center for Translational Pathology · USHenry Ford Health System · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
Engineering sensitive microfluidic multiplex technology for isolating circulatingDP2OD006672 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NAGRATH, SUNITHA · 2009 to 2009
$2.1M
Tunable Polymer-Graphene Oxide Composite for Single Cell Analysis of Breast Cancer CTCs & CSCsR56CA203290 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KIM, JINSANG, NAGRATH, SUNITHA · 2016 to 2016
$300k
NCI NIH HHS P30 CA046592NCI NIH HHS R56 CA203290NIH HHS DP2 OD006672
6 · The paper itself

Abstract

A highly sensitive microfluidic system to capture circulating tumor cells from whole blood of cancer patients is presented. The device incorporates graphene oxide into a thermoresponsive polymer film to serve as the first step of an antibody functionalization chemistry. By decreasing the temperature, captured cells may be released for subsequent analysis.

Indexed as

TemperatureAntibodiesCell SeparationCell SurvivalGraphiteHumansMCF-7 CellsMicrofluidicsNeoplasmsNeoplastic Cells, CirculatingOxidesPolymersAntibodiesGraphiteOxidesPolymersbreast cancercirculating tumor cellgraphene oxidepancreatic cancerthermoresponsive polymer

Identifiers

PMID27115557
PMCPMC5680542
OpenAlexW2343629045

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.