ArticlePLoS computational biology2016
Constraints on Biological Mechanism from Disease Comorbidity Using Electronic Medical Records and Database of Genetic Variants.
Article in PLoS computational biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Applications of network analysis to routinely collected health care data: a systematic review.Journal of the American Medical Informatics Association : JAMIA · 2018Pooled it
- Subjective response to alcohol in young adults with bipolar disorder and recent alcohol use: a within-subject randomized placebo-controlled alcohol administration study.Psychopharmacology · 2023Trial
- The Relationship Between Work-Related Stress and Depression: A Scoping Review.Public health reviews · 2024Article
- Visualizing novel connections and genetic similarities across diseases using a network-medicine based approach.Scientific reports · 2022Article
- Identification of genetic risk loci for depression and migraine comorbidity in Han Chinese residing in Taiwan.Frontiers in psychiatry · 2022Article
- Decoding Neuromuscular Disorders Using Phenotypic Clusters Obtained From Co-Occurrence Networks.Frontiers in molecular biosciences · 2021Article
- Phenotype-genotype comorbidity analysis of patients with rare disorders provides insight into their pathological and molecular bases.PLoS genetics · 2020Article
- Sensitivity of comorbidity network analysis.JAMIA open · 2020Article
- Comorbidity of asthma and hypertension may be mediated by shared genetic dysregulation and drug side effects.Scientific reports · 2019Article
- Exploring the Association between Monoclonal Antibodies and Depression and Suicidal Ideation and Behavior: A VigiBase Study.Drug safety · 2019Article
- The Alzheimer's comorbidity phenome: mining from a large patient database and phenome-driven genetics prediction.JAMIA open · 2019Article
- Novel disease syndromes unveiled by integrative multiscale network analysis of diseases sharing molecular effectors and comorbidities.BMC medical genomics · 2018Article
- Enabling precision medicine in neonatology, an integrated repository for preterm birth research.Scientific data · 2018Article
- comoRbidity: an R package for the systematic analysis of disease comorbidities.Bioinformatics (Oxford, England) · 2018Article
- A Review of Recent Advances in Translational Bioinformatics: Bridges from Biology to Medicine.Yearbook of medical informatics · 2017Review
- Comorbidities in the diseasome are more apparent than real: What Bayesian filtering reveals about the comorbidities of depression.PLoS computational biology · 2017Article
Corrections and comments
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5 authors.
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Abstract
Patterns of disease co-occurrence that deviate from statistical independence may represent important constraints on biological mechanism, which sometimes can be explained by shared genetics. In this work we study the relationship between disease co-occurrence and commonly shared genetic architecture of disease. Records of pairs of diseases were combined from two different electronic medical systems (Columbia, Stanford), and compared to a large database of published disease-associated genetic variants (VARIMED); data on 35 disorders were available across all three sources, which include medical records for over 1.2 million patients and variants from over 17,000 publications. Based on the sources in which they appeared, disease pairs were categorized as having predominant clinical, genetic, or both kinds of manifestations. Confounding effects of age on disease incidence were controlled for by only comparing diseases when they fall in the same cluster of similarly shaped incidence patterns. We find that disease pairs that are overrepresented in both electronic medical record systems and in VARIMED come from two main disease classes, autoimmune and neuropsychiatric. We furthermore identify specific genes that are shared within these disease groups.
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