ArticleJAMA2016
Association Between Rotating Night Shift Work and Risk of Coronary Heart Disease Among Women.
Article in JAMA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05966805 (Examining the Impact of a 12-week Worksite Exercise Training Intervention on Mental, Metabolic, Physical, Spiritual, and Occupational Well-being Among Acute Care Nurses), which is not on this map. Cited by 259 papers, 10 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Examining the Impact of a 12-week Worksite Exercise Training Intervention on Mental, Metabolic, Physical, Spiritual, and Occupational Well-being Among Acute Care Nurses: A Randomized, Controlled Mixed Methods Pilot Study
Who cites it
259 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Long-term night shift work and cardiometabolic health in healthcare workers: a review of mechanisms and precision intervention strategies.Frontiers in public health · 2026Pooled it
- Night shift work and breast cancer risk in healthcare workers: a systematic review and meta-analysis.Occupational medicine (Oxford, England) · 2025Pooled it
- Disrupted Rhythms, Disrupted Microbes: A Systematic Review of Shift Work and Gut Microbiota Alterations.Nutrients · 2025Pooled it
- Association between night shift work and cardiovascular disease: a systematic review and dose-response meta-analysis.Frontiers in public health · 2025Pooled it
- The efficacy of interventions in the workplace promoting exercise and a healthy diet among shift workers: A systematic review.PloS one · 2025Pooled it
- The influence of workplace stressors on the risk of cardiovascular diseases among healthcare providers: a systematic review.Frontiers in psychiatry · 2025Pooled it
- Occupational Risk for Coronary Artery Disease in Shift Workers - A Systematic Review.La Medicina del lavoro · 2024Pooled it
- Sudden cardiac death among workers: a systematic review and meta-analysis.Systematic reviews · 2024Pooled it
- Association of Low Back Pain with Shift Work: A Meta-Analysis.International journal of environmental research and public health · 2023Pooled it
- Work Exposures and Development of Cardiovascular Diseases: A Systematic Review.Annals of work exposures and health · 2022Pooled it
- Efficacy and Adherence to a Supervised Aerobic Exercise Training Intervention in Night-Shift Hospital Nurses: A Randomized Controlled Trial.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Trial
- Low-Dose Melatonin, Climacteric Symptoms and Sleep in Female Shift Workers: A Randomized Controlled Trial.Journal of pineal research · 2026Trial
- Daytime eating during simulated night work mitigates changes in cardiovascular risk factors: secondary analyses of a randomized controlled trial.Nature communications · 2025Trial
- Acute night shift work is associated with increased blood pressure and reduced sleep duration in healthy adults.Physiological reports · 2025Trial
- Chronic Circadian Disruption and Sleep Restriction Influence Subjective Hunger, Appetite, and Food Preference.Nutrients · 2022Trial
- The Risk of Cardiovascular Diseases for Shift Workers in the Prospective Heinz Nixdorf Recall Study.American journal of industrial medicine · 2026Article
- Rotating Night Shift Work and Risk of Incident Cardiovascular Disease and Mortality by Chronotype: A Prospective Cohort Study in Nurses' Health Study II.medRxiv : the preprint server for health sciences · 2026Article
- Status and influencing factors of work-family conflict among operating room nurses in public hospitals: A cross-sectional study.Medicine · 2026Article
- Dynamic prediction of HIV-related incomplete immune reconstitution: A multicenter, large cohort study using advanced joint modeling.Science advances · 2026Article
- Association between adverse childhood experiences and accelerated aging of middle-aged and older Chinese: based on the China health and retirement longitudinal study.BMC public health · 2026Observational
199 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
importanceProspective studies linking shift work to coronary heart disease (CHD) have been inconsistent and limited by short follow-up.
objectiveTo determine whether rotating night shift work is associated with CHD risk. DESIGN, SETTING, AND
participantsProspective cohort study of 189,158 initially healthy women followed up over 24 years in the Nurses' Health Studies (NHS [1988-2012]: N = 73,623 and NHS2 [1989-2013]: N = 115,535). EXPOSURES: Lifetime history of rotating night shift work (≥3 night shifts per month in addition to day and evening shifts) at baseline (updated every 2 to 4 years in the NHS2). MAIN OUTCOMES AND MEASURES: Incident CHD; ie, nonfatal myocardial infarction, CHD death, angiogram-confirmed angina pectoris, coronary artery bypass graft surgery, stents, and angioplasty.
resultsDuring follow-up, 7303 incident CHD cases occurred in the NHS (mean age at baseline, 54.5 years) and 3519 in the NHS2 (mean age, 34.8 years). In multivariable-adjusted Cox proportional hazards models, increasing years of baseline rotating night shift work was associated with significantly higher CHD risk in both cohorts. In the NHS, the association between duration of shift work and CHD was stronger in the first half of follow-up than in the second half (P=.02 for interaction), suggesting waning risk after cessation of shift work. Longer time since quitting shift work was associated with decreased CHD risk among ever shift workers in the NHS2 (P<.001 for trend). [table: see text] CONCLUSIONS AND RELEVANCE: Among women who worked as registered nurses, longer duration of rotating night shift work was associated with a statistically significant but small absolute increase in CHD risk. Further research is needed to explore whether the association is related to specific work hours and individual characteristics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.