ArticleTranslational psychiatry2016
Exercise during early, but not late abstinence, attenuates subsequent relapse vulnerability in a rat model.
Article in Translational psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Exercise as a Neurobiological Intervention: Utilizing NAc Circuitry to Combat Addiction.Addiction neuroscience · 2026Article
- Impact of SMAASH-C, a novel nutritional supplement, on drug-seeking and toxicity in female and male rats.Translational psychiatry · 2024Article
- Exercise Modifies the Brain Metabolic Response to Chronic Cocaine Exposure Inhibiting the Stria Terminalis.Brain sciences · 2023Article
- Transcriptional Profile of Exercise-Induced Protection Against Relapse to Cocaine Seeking in a Rat Model.Biological psychiatry global open science · 2023Article
- Sex/Gender Differences in the Time-Course for the Development of Substance Use Disorder: A Focus on the Telescoping Effect.Pharmacological reviews · 2023Review
- Aerobic exercise as a promising nonpharmacological therapy for the treatment of substance use disorders.Journal of neuroscience research · 2022Review
- Sex differences in the neuroadaptations associated with incubated cocaine-craving: A focus on the dorsomedial prefrontal cortex.Frontiers in behavioral neuroscience · 2022Article
- Sex- and Dose-Dependent Differences in the Development of an Addiction-Like Phenotype Following Extended-Access Fentanyl Self-Administration.Frontiers in pharmacology · 2022Article
- Factors modulating the incubation of drug and non-drug craving and their clinical implications.Neuroscience and biobehavioral reviews · 2021Review
- A buprenorphine-validated rat model of opioid use disorder optimized to study sex differences in vulnerability to relapse.Psychopharmacology · 2021Article
- Therapeutic efficacy of environmental enrichment for substance use disorders.Pharmacology, biochemistry, and behavior · 2020Review
- Exercise during abstinence normalizes ultrastructural synaptic plasticity associated with nicotine-seeking following extended access self-administration.The European journal of neuroscience · 2019Article
- Mechanisms underlying the efficacy of exercise as an intervention for cocaine relapse: a focus on mGlu5 in the dorsal medial prefrontal cortex.Psychopharmacology · 2019Article
- Sex differences in neural mechanisms mediating reward and addiction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Brain and Cognition for Addiction Medicine: From Prevention to Recovery Neural Substrates for Treatment of Psychostimulant-Induced Cognitive Deficits.Frontiers in psychiatry · 2019Review
- Modeling the development of drug addiction in male and female animals.Pharmacology, biochemistry, and behavior · 2018Review
- Exercise as a Sex-Specific Treatment for Substance Use Disorder.Current addiction reports · 2017Article
- Neurobiology of substance use in adolescents and potential therapeutic effects of exercise for prevention and treatment of substance use disorders.Birth defects research · 2017Review
- Physical Exercise Interventions for Drug Addictive Disorders.Journal of reward deficiency syndrome and addiction science · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Exercise has shown promise as a nonpharmacological intervention for addiction, with evidence suggesting a potential utility for relapse prevention. In humans, exercise as an intervention is typically introduced well after the initiation of abstinence, yet neurobiological data from preclinical studies suggest that it may be more effective if initiated during early abstinence. Here, using rat models, we determined whether the beneficial effects of exercise on relapse vulnerability depends on when exercise is first initiated, during early versus late abstinence. Once rats (n=47) acquired cocaine self-administration, they were given 24-h access to cocaine (1.5 mg/kg per infusion) under a discrete trial procedure (four infusions per hour) for 10 days. The rats then began a 14-day abstinence period in which they had access (2 h per day) to a locked wheel throughout abstinence (sedentary) or an unlocked wheel during early (days 1-7), late (days 8-14) or throughout (days 1-14) abstinence (n=10-14 per group). Cocaine seeking, as assessed under an extinction/cued-induced reinstatement procedure, was examined on day 15 of abstinence. Exercise beginning during early abstinence robustly attenuated subsequent cocaine seeking, and this effect persisted even when exercise ended on the seventh day of abstinence. In contrast, exercise during late abstinence was not effective and these animals displayed high levels of cocaine seeking similar to those observed in sedentary animals. These results indicate that the timing of exercise availability differentially impacts cocaine seeking with results suggesting that exercise during early, but not late, abstinence may provide long-term protection against cocaine relapse.
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