ArticleJournal of traditional and complementary medicine2016
Curcumin improves liver damage in male mice exposed to nicotine.
Article in Journal of traditional and complementary medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 62 citations in OpenAlex.
- Cigarette Smoke Contributes to the Progression of MASLD: From the Molecular Mechanisms to Therapy.Cells · 2025Review
- The Interaction of Apical Periodontitis, Cigarette Smoke, and Alcohol Consumption on Liver Antioxidant Status in Rats.International journal of molecular sciences · 2024Article
- Review
- Hypolipidemic and hepatoprotective effects of corn silk extract in nicotine-administered male mice.Gastroenterology and hepatology from bed to bench · 2024Article
- Rutin and Hesperidin Revoke the Hepatotoxicity Induced by Paclitaxel in Male Wistar RatsEvidence-based complementary and alternative medicine : eCAM · 2023Article
- Pathogenesis-Related Gene Expression in Response toFrontiers in veterinary science · 2022Article
- The Antioxidant Properties of Alfalfa (Oxidative medicine and cellular longevity · 2022Article
- Cancer potencies and margin of exposure used for comparative risk assessment of heated tobacco products and electronic cigarettes aerosols with cigarette smoke.Archives of toxicology · 2021Article
- Curcumin-loaded cockle shell-derived calcium carbonate nanoparticles: A novel strategy for the treatment of lead-induced hepato-renal toxicity in rats.Saudi journal of biological sciences · 2020Article
- A Comparative Study of the Toxicity of Polyethylene Glycol-Coated Cobalt Ferrite Nanospheres and Nanoparticles.Nanoscale research letters · 2019Article
- Endothelium-independent and calcium channel-dependent relaxation of the porcine cerebral artery by different species and strains of turmeric.Journal of traditional and complementary medicine · 2019Article
- Effect ofJournal of diabetes and metabolic disorders · 2019Article
- Effect of Harmine on Nicotine-Induced Kidney Dysfunction in Male Mice.International journal of preventive medicine · 2019Article
- Genistein Improves Liver Damage in Male Mice Exposed to Morphine.Chinese medical journal · 2018Article
- Pollution and respiratory disease: can diet or supplements help? A review.Respiratory research · 2018Review
- Toxicity of PEG-Coated CoFeNanoscale research letters · 2018Article
- The Effects of Thymoquinone Against Morphine-induced Damages on Male Mice Liver.International journal of preventive medicine · 2018Article
- Expression Changes of Apoptotic Genes in Tissues from Mice Exposed to NicotineAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Protective effect of crocin on liver toxicity induced by morphine.Research in pharmaceutical sciencesArticle
- Protective Effect of Alpha-Lipoic Acid against Liver Damage Induced by Cigarette Smoke: AnSaudi journal of medicine & medical sciencesArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The color of turmeric ( jiāng huáng) is because of a substance called curcumin. It has different pharmacological effects, such as antioxidant and anti-inflammatory properties. Nicotine is a major pharmacologically active substance in cigarette smoke. It is mainly metabolized in the liver and causes devastating effects. This study was designed to evaluate the protective role of curcumin against nicotine on the liver in mice. Forty-eight mice were equally divided into eight groups; control (normal saline), nicotine (2.5 mg/kg), curcumin (10, 30, and 60 mg/kg) and curcumin plus nicotine-treated groups. Curcumin, nicotine, and curcumin plus nicotine (once a day) were intraperitoneally injected for 4 weeks. The liver weight and histology, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and serum nitric oxide levels have been studied. The results indicated that nicotine administration significantly decreased liver weight and increased the mean diameter of hepatocyte, central hepatic vein, liver enzymes level, and blood serum nitric oxide level compared with the saline group (p < 0.05). However, curcumin and curcumin plus nicotine administration substantially increased liver weight and decreased the mean diameter of hepatocyte, central hepatic vein, liver enzymes, and nitric oxide levels in all groups compared with the nicotine group (p < 0.05). Curcumin demonstrated its protective effect against nicotine-induced liver toxicity.
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