ArticleJournal of traditional and complementary medicine2016
Sedative effects of inhaled essential oil components of traditional fragrance Pogostemon cablin leaves and their structure-activity relationships.
Article in Journal of traditional and complementary medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Sleep-promoting activity of lotus (Pharmaceutical biology · 2022Article
- Olfactory Stimulation Successfully Modulates the Neurochemical, Biochemical and Behavioral Phenotypes of the Visceral Pain.Molecules (Basel, Switzerland) · 2022Article
- Sedative effects of l-menthol, d-camphor, phenylethyl alcohol, and geraniol.Journal of natural medicines · 2021Article
- Sedative effects of the essential oil from the leaves of Lantana camara occurring in the Republic of Benin via inhalation in mice.Journal of natural medicines · 2020Article
- Does patchouli oil change blood platelet monoamine oxidase-A activity of adult mammals?The journal of physiological sciences : JPS · 2018Article
- Anti-stress and neuronal cell differentiation induction effects of Rosmarinus officinalis L. essential oil.BMC complementary and alternative medicine · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants rich in essential oils, such as Pogostemon cablin (P. cablin; guǎng huò xiāng), have been used for aromas and as herbal medicines since ancient times because of their sedative effects. We investigated the sedative effects of hexane extract from P. cablin using locomotor activity in mice. Inhalation of P. cablin hexane extract exhibited significant sedative activity in a dose-dependent manner. In order to isolate the active constituents, the extract was fractionated and diacetone alcohol was identified as an active compound. Inhalation of diacetone alcohol significantly reduced murine locomotor activity in a dose-dependent manner, and this effect was not observed in olfaction-impaired mice. We examined the structure-activity relationship of diacetone alcohol and similar compounds. The ketone group at the two-position and number of carbons may play important roles in the sedative activity of diacetone alcohol.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.