ArticleJournal of neurosciences in rural practice
Effect of root-extracts of Ficus benghalensis (Banyan) in pain in animal models.
Article in Journal of neurosciences in rural practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The trial behind it
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Who cites it
7 citing papers in PubMed.
- A review ofAmerican journal of translational research · 2024Review
- Analysis of salivary steroid hormones in boys with autism spectrum disorder.BMC psychiatry · 2023Article
- In-vitro antioxidant potential and acetylcholinesterase inhibitory effect of Ficus benghalensis aerial root extract.African health sciences · 2022Article
- Phytochemistry, Pharmacological Properties, and Recent Applications ofPlants (Basel, Switzerland) · 2021Review
- Article
- Proposal Allocation Ratio as a Moderator of Interpersonal Responsibility Effects on Hostile Decision-Making in the Ultimatum Game.Frontiers in psychology · 2017Article
- Effect of root-extracts of Ficus benghalensis (Banyan) in memory, anxiety, muscle co-ordination and seizure in animal models.BMC complementary and alternative medicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAccording to the WHO, 70-80% population in developing countries still relies on nonconventional medicine mainly of herbal origin. Even in developed countries, use of herbal medicine is growing each year. Pain is an unpleasant feeling often caused by intense or damaging stimuli. Traditionally, different plant parts of Ficus benghalensis are claimed to have several analgesic properties. Few scientific evidences support these uses. Interestingly, still others contradict these uses. It was shocking to find very scarce scientific studies trying to solve the mystery. MATERIALS AND
methodsIt was a quantitative experimental study in Swiss albino mice of either sex. Sample size was calculated using free sample size calculating software G*Power version 3.1.9.2. Hot-plate test and tail-flick test were central antinociceptive paradigms. Writhing test was peripheral model for pain. Test drugs were aqueous root extracts of F. benghalensis at 100 mg/kg and 200 mg/kg mouse weight prepared by Soxhlet method. Suitable negative and positive controls were used. The experimental results were represented as mean ± standard deviation statistical level of significance was set at P < 0.05. For calculation, parametric test - one-way analysis of variance (ANOVA) or nonparametric test - Mann-Whitney U-test was appropriately used.
resultsHot-plate reaction time at 100 mg/kg (13.64 ± 1.30 s) and 200 mg/kg (10.32 ± 2.23 s) were nonsignificant (P = 0.425 and P = 0.498, respectively) compared to negative control (11.87 ± 1.92 s). One-way ANOVA revealed nonsignificant (P = 0.178) between-group comparison in mean tail-flick reaction time. Test drug at 200 mg/kg produced statistically significant more writhing (36.00 ± 14.85 in 10 min) than negative control, normal saline (11.83 ± 12.43 in 10 min) or the positive control, Indomethacin (3.50 ± 5.21 in 10 min), P value being 0.031 and 0.003, respectively.
conclusionAqueous root extracts of F. benghalensis at 200 mg/kg produces statistically significant writhing.
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