ArticleThe Journal of experimental medicine2016
Genetic functions of the NAIP family of inflammasome receptors for bacterial ligands in mice.
Article in The Journal of experimental medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 96 citations in OpenAlex.
- The NLRP3 inflammasome at the crossroads of innate immune signaling and cell death.Cellular & molecular immunology · 2026Review
- The Co-Evolutionary Arms Race BetweenMicroorganisms · 2026Review
- The role of pyroptosis in ovarian cancer.Discover oncology · 2025Review
- Enteric tuft cell inflammasome activation drives NKp46+ILC3 IL22 via PGD2 and inhibits Salmonella.The Journal of experimental medicine · 2025Article
- Pyroptosis of pulmonary fibroblasts and macrophages through NLRC4 inflammasome leads to acute respiratory failure.Cell reports · 2025Article
- Inflammasomes primarily restrict cytosoliceLife · 2025Article
- Inflammasome protein scaffolds the DNA damage complex during tumor development.Nature immunology · 2024Article
- Inflammasomes primarily restrict cytosolicbioRxiv : the preprint server for biology · 2024Article
- Review
- Mechanisms of host adaptation by bacterial pathogens.FEMS microbiology reviews · 2024Review
- Genetic distribution, characterization, and function ofiScience · 2024Review
- Pyroptosis regulation byFrontiers in immunology · 2024Review
- The NLRP3 inflammasome in burns: a novel potential therapeutic target.Burns & trauma · 2024Review
- Article
- Inflammasome activation and pyroptosis mediate coagulopathy and inflammation in Salmonella systemic infection.Microbiological research · 2023Article
- Article
- Human and mouse NAIP/NLRC4 inflammasome responses to bacterial infection.Current opinion in microbiology · 2023Review
- Inducing Pyroptosis with FlaTox, RodTox, or NeedleTox.Methods in molecular biology (Clifton, N.J.) · 2023Article
- scDual-Seq ofFrontiers in immunology · 2023Article
- The role of NOD-like receptors in innate immunity.Frontiers in immunology · 2023Review
5 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Biochemical studies suggest that the NAIP family of NLR proteins are cytosolic innate receptors that directly recognize bacterial ligands and trigger NLRC4 inflammasome activation. In this study, we generated Naip5(-/-), Naip1(-/-), and Naip2(-/-) mice and showed that bone marrow macrophages derived from these knockout mice are specifically deficient in detecting bacterial flagellin, the type III secretion system needle, and the rod protein, respectively. Naip1(-/-), Naip2(-/-), and Naip5(-/-) mice also resist lethal inflammasome activation by the corresponding ligand. Furthermore, infections performed in the Naip-deficient macrophages have helped to define the major signal in Legionella pneumophila, Salmonella Typhimurium and Shigella flexneri that is detected by the NAIP/NLRC4 inflammasome. Using an engineered S. Typhimurium infection model, we demonstrate the critical role of NAIPs in clearing bacterial infection and protecting mice from bacterial virulence-induced lethality. These results provide definitive genetic evidence for the important physiological function of NAIPs in antibacterial defense and inflammatory damage-induced lethality in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.