ArticleThe American journal of tropical medicine and hygiene2016
Atypical Clinical Presentation of Sporotrichosis Caused by Sporothrix globosa Resistant to Itraconazole.
Article in The American journal of tropical medicine and hygiene, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Chemical modifications of diphenyl diselenide enhance its anti-Sporothrix spp. activity and exhibit synergism with itraconazole.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Immune genes CD247 STAT1 and LCK mediate host-pathogen interactions in sporotrichosis.Scientific reports · 2025Article
- A case report of rapid diagnosis ofFrontiers in medicine · 2025Article
- Sporotrichosis caused byMedical mycology case reports · 2024Article
- Bimodal distribution of azole susceptibility inAntimicrobial agents and chemotherapy · 2024Article
- Human and Feline Sporotrichosis in a Reference Center of Southeastern Brazil: Genetic Differentiation, Diversity, and Antifungal Susceptibility ofJournal of fungi (Basel, Switzerland) · 2023Article
- Current Progress on Epidemiology, Diagnosis, and Treatment of Sporotrichosis and Their Future Trends.Journal of fungi (Basel, Switzerland) · 2022Review
- Epidemiology of Clinical Sporotrichosis in the Americas in the Last Ten Years.Journal of fungi (Basel, Switzerland) · 2022Review
- Biological and Clinical Attributes ofInfection and drug resistance · 2022Review
- Uncommon Clinical Presentations of Sporotrichosis: A Two-Case Report.Pathogens (Basel, Switzerland) · 2021Article
- Diphenyl diselenide alone and in combination with itraconazole against Sporothrix schenckii s.str. and Sporothrix globosa.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Synergism of Nikkomycin Z in Combination with Diphenyl Diselenide Against Sporothrix spp.Current microbiology · 2021Article
- In vitro antifungal susceptibility of Sporothrix globosa isolates from Jilin Province, northeastern China: comparison of yeast and mycelial phases.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Phenotypic and molecular characterisation of Sporothrix globosa of diverse origin from India.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Antifungal resistance on Sporothrix species: an overview.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Review
- The threat of emerging and re-emerging pathogenic Sporothrix species.Mycopathologia · 2020Review
- Sensitivities of periodic acid-Schiff staining, Grocott's silver staining and calcofluor white staining in the diagnosis of human sporotrichosis.International journal of clinical and experimental pathology · 2019Article
- Immunopathogenesis of Human Sporotrichosis: What We Already Know.Journal of fungi (Basel, Switzerland) · 2018Review
- Exploring virulence and immunogenicity in the emerging pathogen Sporothrix brasiliensis.PLoS neglected tropical diseases · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sporotrichosis is a polymorphic disease of humans and animals, which is acquired via traumatic inoculation of Sporothrix propagules into cutaneous or subcutaneous tissue. The etiological agents are in a clinical complex, which includes Sporothrix brasiliensis, Sporothrix schenckii, Sporothrix globosa, and Sporothrix luriei, each of which has specific epidemiological and virulence characteristics. Classical manifestation in humans includes a fixed localized lesion at the site of trauma plus lymphocutaneous sporotrichosis with fungal spreading along the lymphatic channels. Atypical sporotrichosis is a challenge to diagnosis because it can mimic many other dermatological diseases. We report an unusual, itraconazole-resistant cutaneous lesion of sporotrichosis in a 66-year-old Brazilian man. Histopathological examination of the skin revealed vascular and fibroblastic proliferation with chronic granulomatous infiltrate composed of multinucleated giant cells. Sporothrix were isolated from the skin lesion, and phylogenetic analyses confirmed it to be sporotrichosis due to S. globosa, a widespread pathogen. Immunoblotting analysis showed several IgG-reactive molecules in autochthonous preparations of the whole cellular proteins (160, 80, 60, 55, 46, 38, 35, and 30 kDa) and exoantigen (35 and 33 kDa). The patient was first unsuccessfully treated with daily itraconazole, and then successfully treated with potassium iodide.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.