Evidence map›Paper›PMID 27114259›Full record

ArticleForensic science, medicine, and pathology2016

Hyoid bone fusion and bone density across the lifespan: prediction of age and sex.

Ellie Fisher, Diane Austin, Helen M Werner, Ying Ji Chuang, Edward Bersu, Houri K Vorperian

Abstract read
In one paragraph

Article in Forensic science, medicine, and pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ellie FisherVocal Tract Development Lab, Waisman Center, University of Wisconsin-Madison, 1500 Highland Ave, Rm 427, Madison, WI, 53705-2280, USA.
Diane AustinVocal Tract Development Lab, Waisman Center, University of Wisconsin-Madison, 1500 Highland Ave, Rm 427, Madison, WI, 53705-2280, USA.
Helen M WernerVocal Tract Development Lab, Waisman Center, University of Wisconsin-Madison, 1500 Highland Ave, Rm 427, Madison, WI, 53705-2280, USA.
Ying Ji ChuangVocal Tract Development Lab, Waisman Center, University of Wisconsin-Madison, 1500 Highland Ave, Rm 427, Madison, WI, 53705-2280, USA.
Edward BersuSchool of Medicine and Public Health, University of Wisconsin-Madison, 1300 University Avenue, Madison, WI, 53706, USA.
Houri K VorperianVocal Tract Development Lab, Waisman Center, University of Wisconsin-Madison, 1500 Highland Ave, Rm 427, Madison, WI, 53705-2280, USA. vorperian@waisman.wisc.edu.

Funding

WISCONSIN CENTER ON MENTAL RETARDATION: CORE SUPPORTP30HD003352 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI MESSING, ALBEE · 1985 to 2015
$25.2M
MRI &CT Studies of the Developing Vocal TractR01DC006282 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI VORPERIAN, HOURI KALOUSTIAN · 2003 to 2018
$7.9M
NICHD NIH HHS P30 HD003352NIDCD NIH HHS R01 DC006282
6 · The paper itself

Abstract

The hyoid bone supports the important functions of swallowing and speech. At birth, the hyoid bone consists of a central body and pairs of right and left lesser and greater cornua. Fusion of the greater cornua with the body normally occurs in adulthood, but may not occur at all in some individuals. The aim of this study was to quantify hyoid bone fusion across the lifespan, as well as assess developmental changes in hyoid bone density. Using a computed tomography imaging studies database, 136 hyoid bones (66 male, 70 female, ages 1-to-94) were examined. Fusion was ranked on each side and hyoid bones were classified into one of four fusion categories based on their bilateral ranks: bilateral distant non-fusion, bilateral non-fusion, partial or unilateral fusion, and bilateral fusion. Three-dimensional hyoid bone models were created and used to calculate bone density in Hounsfield units. Results showed a wide range of variability in the timing and degree of hyoid bone fusion, with a trend for bilateral non-fusion to decrease after age 20. Hyoid bone density was significantly lower in adult female scans than adult male scans and decreased with age in adulthood. In sex and age estimation models, bone density was a significant predictor of sex. Both fusion category and bone density were significant predictors of age group for adult females. This study provides a developmental baseline for understanding hyoid bone fusion and bone density in typically developing individuals. Findings have implications for the disciplines of forensics, anatomy, speech pathology, and anthropology.

Indexed as

AdolescentAdultAgedAged, 80 and overAge Determination by SkeletonBone DensityChildChild, PreschoolFemaleForensic AnthropologyHumansHyoid BoneImaging, Three-DimensionalInfantMaleMiddle Aged3D modelingBone densityComputed tomographyForensic scienceHyoid bone fusionIn vivo

Identifiers

PMID27114259
PMCPMC4859847

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.