ArticleMicrocirculation (New York, N.Y. : 1994)2016
Microvascular Response in Patients with Complex Regional Pain Syndrome as Measured by Laser Doppler Imaging.
Article in Microcirculation (New York, N.Y. : 1994), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Diagnostic Criteria and Technical Evaluation of Complex Regional Pain Syndrome: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Physiological Effects of Local Theragun™ Application: An Observational Study in Healthy Female Participants.International journal of sports physical therapy · 2025Article
- Article
- Complex Regional Pain Syndrome (CRPS) and the Value of Early Detection.Current pain and headache reports · 2023Review
- Effect of different thermal stimuli on improving microcirculation in the contralateral foot.Biomedical engineering online · 2021Article
- Complex regional pain syndrome: a focus on the autonomic nervous system.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019Review
- Microvascular Response in Patients with Complex Regional Pain Syndrome as Measured by Laser Doppler Imaging.Microcirculation (New York, N.Y. : 1994) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesOur aim was to investigate the hypothesis that microvascular dysfunction occurs in patients with CRPS. Specifically, whether there were functional differences in either deeper cutaneous blood vessels or more superficial nutritive vessels between the affected and unaffected limb in patients with CRPS, and between CRPS patients and healthy control subjects.
methodsTwenty-two patients with CRPS (five male; mean age 45 years; eight upper limb involvement, 14 lower limb) and 23 healthy control subjects (one male; 43 years) were recruited. Microvascular flow at affected and unaffected contralateral sites was measured, following local heating, using laser Doppler imaging (red/green wavelengths). Corresponding sites were imaged in healthy controls. Maximum flux level and area under the curve (first 20 scans, AUC20) were measured.
resultsVasodilator responses to heat were similar in affected and unaffected limbs, and in healthy controls. For example, median (IQR) "red" AUC20 in CRPS was 138.6 (120.0-152.9)% change from baseline in affected limb and 135.0 (120.7-166.8)% in unaffected limb, and (in healthy controls) 133.1 (117.2-145.9)% and 139.1% (126.0-162.1) in limb 1 and 2.
conclusionsWe found no impairment of vasodilation in cutaneous microvessels in CRPS. The vasomotor changes in CRPS may relate to larger vessel dysfunction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.