ReviewClinical reviews in allergy & immunology2016
Angioedema Phenotypes: Disease Expression and Classification.
Review in Clinical reviews in allergy & immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Related factors with orolingual angioedema after intravenous alteplase in acute ischemic stroke: results from a single-center cohort and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Pooled it
- Ecological momentary assessment to uncover affect dynamics in patients with hereditary angioedema: a complementary tool for enhancing quality of life evaluation.Frontiers in psychology · 2026Article
- Behavioural withdrawal during an acute stress test as a marker of psychobiological vulnerability in hereditary angioedema.Frontiers in immunology · 2026Article
- Acquired Angioedema Related to Transient C1- Inhibitor Deficiency Triggered byReports (MDPI) · 2025Article
- Etiology, Recent Advances, and Clinical Trials Data for the Treatment of Angioedema: A Review.Reviews on recent clinical trials · 2025Review
- Pediatric Angioedema without Wheals: How to Guide the Diagnosis.Life (Basel, Switzerland) · 2023Article
- 3D facial analysis for rare disease diagnosis and treatment monitoring: Proof-Of-Concept plan for hereditary angioedema.PLOS digital health · 2023Article
- C1-inhibitor/C1-inhibitor antibody complexes in acquired angioedema due to C1-inhibitor deficiency.Orphanet journal of rare diseases · 2023Article
- Long term follow-up of complement parameters to improve the management of acquired angioedema due to C1-inhibitor deficiency.Heliyon · 2022Article
- Angioedema with Three Possible Etiologies.Kansas journal of medicine · 2022Article
- Identification of Effective and Nonpromiscuous Antidiabetic Drug Molecules fromEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Biomarkers in Hereditary Angioedema.Clinical reviews in allergy & immunology · 2021Review
- Leveraging Genetics for Hereditary Angioedema: A Road Map to Precision Medicine.Clinical reviews in allergy & immunology · 2021Review
- When the Red Tide Rolls In: A Red Tide Associated Angioedema Case Report.Clinical practice and cases in emergency medicine · 2021Article
- Therapeutic management of hereditary angioedema: past, present, and future.Balkan medical journal · 2021Article
- Recurrent angioedema: Experience at a tertiary care urban medical center.Laryngoscope investigative otolaryngology · 2021Article
- Hereditary Angioedema with and Without C1-Inhibitor Deficiency in Postmenopausal Women.Journal of clinical immunology · 2021Article
- Angioedema. Interdisciplinary diagnostic and therapeutic recommendations of the Polish Dermatological Society (PTD) and Polish Society of Allergology (PTA).Postepy dermatologii i alergologii · 2020Article
- Genetic variants ofCentral-European journal of immunology · 2020Article
- Significant predictive factors of the severity and outcomes of the first attack of acute angioedema in children.BMC pediatrics · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to marked heterogeneity of clinical presentations, comprehensive knowledge of angioedema phenotypes is crucial for correct diagnosis and choosing the appropriate therapeutic approach. One of the ways to a meaningful clinical distinction can be made between forms of angioedema occurring "with or without wheals." Angioedema with wheals (rash) is a hallmark of urticaria, either acute or chronic, spontaneous or inducible. Angioedema without wheals may still be manifested in about 10 % of patients with urticaria, but it may also occur as a separate entity. Several classifications of angioedema as part of urticaria were published over time, while a latest one, released in 2014 (HAWK group consensus, see below), provided a classification of all forms of "angioedema without wheals" distinct from urticaria, which will be the focus of the present review. At this time, the HAWK consensus classification is the best in terms of covering the pathophysiology, mediators involved, angioedema triggers, and clinical expression. According to this classification, three types of hereditary angioedema (genetic C1-INH deficiency, normal C1-INH with factor XII mutations, and unknown origin) and four types of acquired angioedema (C1-INH deficiency, related to ACE inhibitors intake, idiopathic histaminergic, and idiopathic non-histaminergic) are presented. We will review the distinctive clinical features of each phenotype in details.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.