ArticleThe Plant cell2016
Feedback Regulation of DYT1 by Interactions with Downstream bHLH Factors Promotes DYT1 Nuclear Localization and Anther Development.
Article in The Plant cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed.
- Timing it right: dephosphorylation of a key transcription factor constrains the tapetal transcriptional cascade for timely pollen development.The Plant cell · 2026Article
- Genome-wide characterization of the LBD gene family in Sapindus mukorossi and functional analysis of the role of SmuLBD26 in male sterility.Plant cell reports · 2026Article
- GmTGA9-GmDYT1 Regulates Anther Wall Development to Affect Male Fertility in Soybean.Plants (Basel, Switzerland) · 2026Article
- ICE1 plays a vital role in the development of pollen grains through regulating tapetum degradation and nutrient mobilization in Arabidopsis thaliana.Plant molecular biology · 2026Article
- Glycine max Jumonji C domain-containing proteins JMJ19/20 exhibit endopeptidase activity and interact with LUXs to mediate flowering time.Nucleic acids research · 2026Article
- Comprehensive genomic identification and functional analysis ofChinese herbal medicines · 2026Article
- Genome-wide identification and characterization of the Trihelix transcription factor family and functional analysis of VaTrihelix23 under low temperatures stress in Vitis amurensis.BMC plant biology · 2025Article
- CLE19 suppresses brassinosteroid signaling output via the BSL-BIN2 module to maintain BES1 activity and pollen exine patterning in Arabidopsis.Journal of integrative plant biology · 2025Article
- The basic helix-loop-helix (bHLH) transcription factor DTT1 is part of a paired key that unlocks the tapetum transition in barley anther development.The Plant cell · 2025Article
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- Identification of bHLH transcription factors and screening of anthocyanin-related genes in Lagerstroemia indica.Genetica · 2024Article
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- Environmental regulation of male fertility is mediated through Arabidopsis transcription factors bHLH89, 91, and 10.Journal of experimental botany · 2024Article
- Transcription Factors and Their Regulatory Roles in the Male Gametophyte Development of Flowering Plants.International journal of molecular sciences · 2024Review
- bHLH-regulated routes in anther development in rice and Arabidopsis.Genetics and molecular biology · 2024Article
- Barley TAPETAL DEVELOPMENT and FUNCTION1 (HvTDF1) gene reveals conserved and unique roles in controlling anther tapetum development in dicot and monocot plants.The New phytologist · 2023Article
- PXL1 and SERKs act as receptor-coreceptor complexes for the CLE19 peptide to regulate pollen development.Nature communications · 2023Article
- Antagonistic regulation of target genes by the SISTER OF TM3-JOINTLESS2 complex in tomato inflorescence branching.The Plant cell · 2023Article
- Evolution and diversification of the ACT-like domain associated with plant basic helix-loop-helix transcription factors.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
8 more citing papers are in PubMed but not listed here.
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcriptional regulation is one of the most important mechanisms controlling development and cellular functions in plants and animals. The Arabidopsis thaliana bHLH transcription factor (TF) DYSFUNCTIONL TAPETUM1 (DYT1) is required for normal male fertility and anther development and activates the expression of the bHLH010/bHLH089/bHLH091 genes. Here, we showed that DYT1 is localized to both the cytoplasm and nucleus at anther stage 5 but specifically to the nucleus at anther stage 6 and onward. The bHLH010/bHLH089/bHLH091 proteins have strong nuclear localization signals, interact with DYT1, and facilitate the nuclear localization of DYT1. We further found that the conserved C-terminal BIF domain of DYT1 is required for its dimerization, nuclear localization, transcriptional activation activity, and function in anther development. Interestingly, when the BIF domain of DYT1 was replaced with that of bHLH010, the DYT1(N)-bHLH010(BIF) chimeric protein shows nuclear-preferential localization at anther stage 5 but could not fully rescue the dyt1-3 phenotype, suggesting that the normal spatio-temporal subcellular localization of DYT1 is important for DYT1 function and/or that the BIF domains from different bHLH members might be functionally distinct. Our results support an important positive feedback regulatory mechanism whereby downstream TFs increase the function of an upstream TF by enhancing its nucleus localization through the BIF domain.
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