ReviewInternational journal of obesity (2005)2016
Pediatric obesity pharmacotherapy: current state of the field, review of the literature and clinical trial considerations.
Review in International journal of obesity (2005), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Comparative effectiveness of school-based obesity prevention programs for children and adolescents: a systematic review and network meta-analysis.Frontiers in public health · 2024Pooled it
- Effectiveness of Information and Communication Technology on Obesity in Childhood and Adolescence: Systematic Review and Meta-analysis.Journal of medical Internet research · 2021Pooled it
- Pooled it
- Exenatide for weight-loss maintenance in adolescents with severe obesity: A randomized, placebo-controlled trial.Obesity (Silver Spring, Md.) · 2022Trial
- Meal replacements followed by topiramate for the treatment of adolescent severe obesity: A pilot randomized controlled trial.Obesity (Silver Spring, Md.) · 2016Trial
- Application of a reverse consultation model for pediatric obesity care: A quality improvement initiative.Preventive medicine reports · 2025Article
- Tracking the Prevalence of Obesity in Portuguese School-Aged Children: What Future to Expect?Children (Basel, Switzerland) · 2024Article
- Long-term weight loss after bariatric procedures for morbidly obese adolescents and youth: a single-institution analysis with up to 19-year follow-up.Surgical endoscopy · 2023Article
- Vicious cycle between severity of childhood obesity and pandemic: Potential impact of metformin.Obesity medicine · 2022Article
- Aversion to Off-label Prescribing in Clinical Pediatric Weight Management: The Quintessential Double Standard.The Journal of clinical endocrinology and metabolism · 2021Article
- Readiness to Change and Prospective Effects of Weight Management Programs in Pediatric Nonalcoholic Fatty Liver Disease.Clinical and translational science · 2021Observational
- Efficacy of Weight Reduction on Pediatric Nonalcoholic Fatty Liver Disease: Opportunities to Improve Treatment Outcomes Through Pharmacotherapy.Frontiers in endocrinology · 2021Article
- Strategies in the Management of Adolescent Obesity.Current pediatrics reports · 2020Article
- Obesity Treatment Among Adolescents: A Review of Current Evidence and Future Directions.JAMA pediatrics · 2020Review
- Pharmacotherapy for the Treatment of Overweight and Obesity in Children, Adolescents, and Young Adults in a Large Health System in the US.Frontiers in endocrinology · 2020Article
- Severe Obesity in the Pediatric Population: Current Concepts in Clinical Care.Current obesity reports · 2019Review
- Pilot Testing of a Patient Decision Aid for Adolescents with Severe Obesity in US Pediatric Weight Management Programs within the COMPASS Network.International journal of environmental research and public health · 2019Article
- Use of Lisdexamfetamine to Treat Obesity in an Adolescent with Severe Obesity and Binge Eating.Children (Basel, Switzerland) · 2019Article
- Heterogeneity in Response to Treatment of Adolescents with Severe Obesity: The Need for Precision Obesity Medicine.Obesity (Silver Spring, Md.) · 2019Article
- Clinical Considerations Regarding the Use of Obesity Pharmacotherapy in Adolescents with Obesity.Obesity (Silver Spring, Md.) · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Despite the increasing number of medications recently approved to treat obesity among adults, few agents have been formally evaluated in children or adolescents for this indication. Moreover, there is a paucity of guidance in the literature addressing best practices with regard to pediatric obesity pharmacotherapy clinical trial design, and only general recommendations have been offered by regulatory agencies on this topic. The purposes of this article are to (1) offer a background of the current state of the field of pediatric obesity medicine, (2) provide a brief review of the literature summarizing pediatric obesity pharmacotherapy clinical trials, and (3) highlight and discuss some of the unique aspects that should be considered when designing and conducting high-quality clinical trials evaluating the safety and efficacy of obesity medications in children and adolescents. Suggestions are offered in the areas of target population and eligibility criteria, clinical trial end-point selection, trial duration, implementation of lifestyle modification therapy and recruitment and retention of participants. Efforts should be made to design and conduct trials appropriately to ensure that high-quality evidence is generated on the safety and efficacy of various medications used to treat pediatric obesity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.