Evidence map›Paper›PMID 27113584›Full record

ArticleProtein & cell2016

Non-catalytic roles for TET1 protein negatively regulating neuronal differentiation through srGAP3 in neuroblastoma cells.

Jie Gao, Yue Ma, Hua-Lin Fu, Qian Luo, Zhen Wang, Yu-Huan Xiao, Hao Yang, Da-Xiang Cui, Wei-Lin Jin

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein & cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. New Insights into TETs in Psychiatric Disorders.International journal of molecular sciences · 2022
    Review
  6. The emerging roles of srGAPs in cancer.Molecular biology reports · 2022
    Review
  7. Luteolin Modulates Neural Stem Cells Fate Determination:Frontiers in cell and developmental biology · 2021
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jie GaoSchool of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Yue MaInstitute of Nano Biomedicine and Engineering, Department of Instrument Science and Engineering, School of Electronic Information and Electronic Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Hua-Lin FuInstitute of Nano Biomedicine and Engineering, Department of Instrument Science and Engineering, School of Electronic Information and Electronic Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Qian LuoSchool of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Zhen WangInstitute of Nano Biomedicine and Engineering, Department of Instrument Science and Engineering, School of Electronic Information and Electronic Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Yu-Huan XiaoSchool of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Hao YangClinical Stem Cell Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Da-Xiang CuiInstitute of Nano Biomedicine and Engineering, Department of Instrument Science and Engineering, School of Electronic Information and Electronic Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Wei-Lin JinSchool of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China. weilinjin@sjtu.edu.cn.
Shanghai Jiao Tong University · CNAir Force Medical University · CNRenji Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The methylcytosine dioxygenases TET proteins (TET1, TET2, and TET3) play important regulatory roles in neural function. In this study, we investigated the role of TET proteins in neuronal differentiation using Neuro2a cells as a model. We observed that knockdown of TET1, TET2 or TET3 promoted neuronal differentiation of Neuro2a cells, and their overexpression inhibited VPA (valproic acid)-induced neuronal differentiation, suggesting all three TET proteins negatively regulate neuronal differentiation of Neuro2a cells. Interestingly, the inducing activity of TET protein is independent of its enzymatic activity. Our previous studies have demonstrated that srGAP3 can negatively regulate neuronal differentiation of Neuro2a cells. Furthermore, we revealed that TET1 could positively regulate srGAP3 expression independent of its catalytic activity, and srGAP3 is required for TET-mediated neuronal differentiation of Neuro2a cells. The results presented here may facilitate better understanding of the role of TET proteins in neuronal differentiation, and provide a possible therapy target for neuroblastoma.

Indexed as

AnimalsCatalytic DomainCell DifferentiationCell Line, TumorDNA-Binding ProteinsEnzyme InhibitorsGTPase-Activating ProteinsImmunohistochemistryMiceMicroscopy, FluorescenceNeuroblastomaProtein IsoformsProto-Oncogene ProteinsRNA InterferenceRNA, MessengerRNA, Small InterferingDNA-Binding ProteinsEnzyme InhibitorsGTPase-Activating ProteinsProtein IsoformsProto-Oncogene ProteinsRNA, MessengerRNA, Small InterferingSrgap3 protein, mouseTET1 protein, mouseValproic Acidmethylcytosine dioxygenaseneuroblastoma cellsneuronal differentiationsrGAP3TET1

Identifiers

PMID27113584
PMCPMC4853314
OpenAlexW2343636813

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.