ArticleJournal of biomechanics2016
A structural finite element model for lamellar unit of aortic media indicates heterogeneous stress field after collagen recruitment.
Article in Journal of biomechanics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- Bulk density-calibrated fiber networks reveal local weakness as the driver of protease-dependent aortic failure.International journal of engineering science · 2026Article
- Load Transfer along Continuous Collagen Fibers Reduces the Importance of Wall Thickness Variations.ArXiv · 2025Article
- Sex- and region-specific differences in microstructural remodeling and passive biomechanics of the aorta correlate with aneurysm propensity in a mouse model of severe Marfan syndrome.Acta biomaterialia · 2025Article
- Mechanisms of aortic dissection: From pathological changes to experimental andProgress in materials science · 2025Article
- Effect of Collagen Fiber Tortuosity Distribution on the Mechanical Response of Arterial Tissues.Journal of biomechanical engineering · 2025Article
- Effects of Implemented Residual Stresses on Mechanical Responses and Behavior of the Full-Layered Murine Aortic Medial Ring: A Parametric Finite Element Study.Cardiovascular engineering and technology · 2025Article
- Aortic tissue stiffness and tensile strength are correlated with density changes following proteolytic treatment.Journal of biomechanics · 2024Article
- A discrete fiber network finite element model of arterial elastin network considering inter-fiber crosslinking property and density.Journal of the mechanical behavior of biomedical materials · 2022Article
- Biophotonic tools for probing extracellular matrix mechanics.Matrix biology plus · 2021Article
- An exploratory assessment of stretch-induced transmural myocardial fiber kinematics in right ventricular pressure overload.Scientific reports · 2021Article
- Effect of macro-calcification on the failure mechanics of intracranial aneurysmal wall tissue.Experimental mechanics · 2021Article
- Computational modeling of the strength of the ascending thoracic aortic media tissue under physiologic biaxial loading conditions.Journal of biomechanics · 2020Article
- Mechanisms of increased vascular stiffness down the aortic tree in aging, premenopausal female monkeys.American journal of physiology. Heart and circulatory physiology · 2020Article
- Modeling lamellar disruption within the aortic wall using a particle-based approach.Scientific reports · 2019Article
- Structural modeling reveals microstructure-strength relationship for human ascending thoracic aorta.Journal of biomechanics · 2018Article
- Bio-chemo-mechanics of thoracic aortic aneurysms.Current opinion in biomedical engineering · 2018Article
- Multiscale mechanics of the cervical facet capsular ligament, with particular emphasis on anomalous fiber realignment prior to tissue failure.Biomechanics and modeling in mechanobiology · 2018Article
- Growth Description for Vessel Wall Adaptation: A Thick-Walled Mixture Model of Abdominal Aortic Aneurysm Evolution.Materials (Basel, Switzerland) · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Incorporation of collagen structural information into the study of biomechanical behavior of ascending thoracic aortic (ATA) wall tissue should provide better insight into the pathophysiology of ATA. Structurally motivated constitutive models that include fiber dispersion and recruitment can successfully capture overall mechanical response of the arterial wall tissue. However, these models cannot examine local microarchitectural features of the collagen network, such as the effect of fiber disruptions and interaction between fibrous and non-fibrous components, which may influence emergent biomechanical properties of the tissue. Motivated by this need, we developed a finite element based three-dimensional structural model of the lamellar units of the ATA media that directly incorporates the collagen fiber microarchitecture. The fiber architecture was computer generated utilizing network features, namely fiber orientation distribution, intersection density and areal concentration, obtained from image analysis of multiphoton microscopy images taken from human aneurysmal ascending thoracic aortic media specimens with bicuspid aortic valve (BAV) phenotype. Our model reproduces the typical J-shaped constitutive response of the aortic wall tissue. We found that the stress state in the non-fibrous matrix was homogeneous until the collagen fibers were recruited, but became highly heterogeneous after that event. The degree of heterogeneity was dependent upon local network architecture with high stresses observed near disrupted fibers. The magnitude of non-fibrous matrix stress at higher stretch levels was negatively correlated with local fiber density. The localized stress concentrations, elucidated by this model, may be a factor in the degenerative changes in aneurysmal ATA tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.