ArticleBiological psychiatry2017
Extended Amygdala to Ventral Tegmental Area Corticotropin-Releasing Factor Circuit Controls Binge Ethanol Intake.
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Article in Biological psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
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94citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
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Who cites it
94 citing papers in PubMed, 142 citations in OpenAlex.
- A Preliminary, Open-Label Study of Naltrexone and Bupropion Combination Therapy for Treating Binge Drinking in Human Subjects.Alcohol and alcoholism (Oxford, Oxfordshire) · 2020Trial
- Regulation of amygdala and dopamine system in naïve and chronic alcohol states.Alcohol (Fayetteville, N.Y.) · 2026Article
- CCK2R regulates METH-induced CPP acquisition within VTA-BLA-BNST circuit in male mice.Translational psychiatry · 2026Article
- Sex-Specific Effects of Hypocretin Receptor Signaling in Corticotropin-Releasing Factor Neurons on Alcohol Drinking, Anxiety, and Extended Amygdala Neuronal Excitability.Biological psychiatry global open science · 2026Article
- The bed nucleus of the stria terminalis as a neuromodulatory target for refractory epilepsy.Frontiers in network physiology · 2026Review
- Disentangling the effects of corticotrophin releasing factor and GABA release from the bed nucleus of the stria terminalis on ethanol self-administration in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Lateral hypothalamus CRFR1 regulation of chronic binge drinking: divergence along anterior-posterior axis.bioRxiv : the preprint server for biology · 2025Article
- Alcohol consumption drives sex- and region- specific disruption of somatostatin signaling in mice.bioRxiv : the preprint server for biology · 2025Article
- Evidence for independent actions of the CRF and ghrelin systems in binge-like alcohol drinking in mice.Progress in neuro-psychopharmacology & biological psychiatry · 2025Article
- The link between early-life adversity and later alcohol use disorder: A role for microglia?Neurobiology of stress · 2025Article
- Neural Circuitries and Alcohol Use Disorder: Cutting Corners in the Cycle.Current topics in behavioral neurosciences · 2025Review
- Corticotropin-Releasing Factor Modulates Binge-Like Ethanol Drinking in a Sex-Dependent Manner: Impact of Amygdala Deletion and Inhibition of a Central Amygdala to Lateral Hypothalamus Circuit.Biological psychiatry global open science · 2025Article
- Synaptic Effects Induced by Alcohol.Current topics in behavioral neurosciences · 2025Review
- Rapid nongenomic estrogen signaling controls alcohol drinking behavior in mice.Nature communications · 2024Article
- BNST GluN2D-containing NMDARs contribute to ethanol intake but not negative affective behaviors in female mice.Alcohol, clinical & experimental research · 2024Article
- Article
- Chronic alcohol consumption alters sex-dependent BNST neuron function in rhesus macaques.Neurobiology of stress · 2024Article
- Dopamine D2 receptors in the bed nucleus of the stria terminalis modulate alcohol-related behaviors.Addiction neuroscience · 2024Article
- Acute and chronic alcohol modulation of extended amygdala calcium dynamics.Alcohol (Fayetteville, N.Y.) · 2024Article
- Chronic alcohol consumption alters sex-dependent BNST neuron function in rhesus macaques.bioRxiv : the preprint server for biology · 2024Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Jennifer A RinkerDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
S Alex MarshallDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Christopher M MazzoneBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Pharmacology, University of North Carolina at Chapel Hill, , Chapel Hill, North Carolina.
Emily G Lowery-GiontaBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Pharmacology, University of North Carolina at Chapel Hill, , Chapel Hill, North Carolina.
Varun GulatiDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Kristen E PleilDepartment of Pharmacology, University of North Carolina at Chapel Hill, , Chapel Hill, North Carolina.
Thomas L KashBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Pharmacology, University of North Carolina at Chapel Hill, , Chapel Hill, North Carolina.
Montserrat NavarroDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Todd E ThieleDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Electronic address: thiele@unc.edu.
University of North Carolina at Chapel Hill · US
Funding
UNC ARC Information/Dissemination CoreP60AA011605 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A Herman · 2003 to 2026
$46.3MSEEDING POSTDOCTORAL INNOVATORS IN RESEARCH &EDUCATIONK12GM000678 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DONALD T LYSLE, Kathryn Joanna Reissner · 1999 to 2026
$30.9MNeuropeptide Y: Role in Ethanol Intake and SensitivityR01AA013573 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI THIELE, TODD ERIC · 2001 to 2018
$3.8MThe role of corticotropin releasing factor in binge-like ethanol drinkingR01AA022048 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Thomas L. Kash, TODD Eric THIELE · 2013 to 2026
$3.2MNeuropeptide Y: Role in Ethanol Intake and SensitivityR37AA013573 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TODD Eric THIELE · 2019 to 2026
$3.0MMelanocortin Neuropeptides &Ethanol IntakeR01AA015148 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI THIELE, TODD ERIC · 2005 to 2014
$2.5MCore 1: Brain Circuit Validation CoreU24AA025475 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KASH, THOMAS L. · 2017 to 2021
$1.1MAdolescent binging augments adult alcohol intake: A role of histone methylationR21AA022044 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI THIELE, MONTSERRAT NAVARRO · 2014 to 2015
$394kThe role of excitatory inputs to BNST CRF neurons in alcohol drinking behaviorK99AA023559 · NIAAA · WEILL MEDICAL COLL OF CORNELL UNIV · PI PLEIL, KRISTEN ELIZABETH · 2015 to 2016
$228kThe effect of alcohol drinking on NPY modulation of inhibition in the BNSTF32AA021043 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PLEIL, KRISTEN ELIZABETH · 2012 to 2014
$156kEthanol effects on GABA-serotonin interactions in the Dorsal Raphe NucleusF32AA022549 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LOWERY-GIONTA, EMILY GEYER · 2014 to 2015
$112kHistone Methylation: a role in excessive ethanol intake and self-administrationF32AA021611 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RINKER, JENNIFER ANNE · 2012 to 2014
$102kNIAAA NIH HHS F31 AA017818NIAAA NIH HHS F31 AA023440NIAAA NIH HHS F32 AA021043NIAAA NIH HHS F32 AA021611NIAAA NIH HHS F32 AA022549NIAAA NIH HHS K99 AA023559NIAAA NIH HHS P60 AA011605NIAAA NIH HHS R01 AA013573NIAAA NIH HHS R01 AA015148NIAAA NIH HHS R01 AA022048NIAAA NIH HHS R21 AA022044NIAAA NIH HHS R37 AA013573NIAAA NIH HHS U24 AA025475NIGMS NIH HHS K12 GM000678
Abstract
backgroundCorticotropin-releasing factor (CRF) signaling at the CRF
methodsThe effects of binge-like ethanol consumption on the VTA CRF system were assessed following drinking-in-the-dark procedures. Intra-VTA infusions of selective CRF
resultsIntra-VTA antagonism of CRF
conclusionsWe provide novel evidence that 1) blunted binge-like ethanol consumption stemming from CRF
Indexed as
AcenaphthenesAnimalsBinge DrinkingClozapineCorticotropin-Releasing HormoneCRF Receptor, Type 1Designer DrugsMaleMiceMice, TransgenicNeural PathwaysPyrimidinesPyrrolesReceptors, Corticotropin-Releasing HormoneSeptal NucleiUrocortins6-cyclopropylmethyl-2-(2,4-dichlorophenyl)-7-ethyl-4-methyl-7,8-dihydro-6H-1,3,6,8a-tetraazaacenaphthyleneAcenaphthenesantalarminClozapineclozapine N-oxideCorticotropin-Releasing HormoneCRF Receptor, Type 1CRF receptor type 2Designer DrugsPyrimidinesPyrrolesReceptors, Corticotropin-Releasing HormoneUrocortinsBinge drinkingCorticotropin-releasing factorDrinking in the darkEthanolExtended amygdalaVentral tegmental area
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.