ArticleInternational journal of obesity (2005)2016
Epigenomic elements analyses for promoters identify ESRRG as a new susceptibility gene for obesity-related traits.
Article in International journal of obesity (2005), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Activation of estrogen-related receptor γ by calcium and cadmium.Frontiers in endocrinology · 2024Article
- Environment- and epigenome-wide association study of obesity in 'Children of 1997' birth cohort.eLife · 2023Article
- Comparative Analysis of Promoters and Enhancers in the Pituitary Glands of the Bama Xiang and Large White Pigs.Frontiers in genetics · 2021Article
- Bioinformatic gene analysis for possible biomarkers and therapeutic targets of hypertension-related renal cell carcinoma.Translational andrology and urology · 2020Article
- Multiomics dissection of molecular regulatory mechanisms underlying autoimmune-associated noncoding SNPs.JCI insight · 2020Article
- Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution.Pharmacological reviews · 2020Review
- Circular RNA Expression Profiles in Nasopharyngeal Carcinoma by Sequence Analysis.Frontiers in oncology · 2020Article
- Addressing the Missing Heritability Problem With the Help of Regulatory Features.Evolutionary bioinformatics online · 2019Article
- Localization of adaptive variants in human genomes using averaged one-dependence estimation.Nature communications · 2018Article
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Authors and funding
11 authors.
Funding
Abstract
objectivesWith ENCODE epigenomic data and results from published genome-wide association studies (GWASs), we aimed to find regulatory signatures of obesity genes and discover novel susceptibility genes.
methodsObesity genes were obtained from public GWAS databases and their promoters were annotated based on the regulatory element information. Significantly enriched or depleted epigenomic elements in the promoters of obesity genes were evaluated and all human genes were then prioritized according to the existence of the selected elements to predict new candidate genes. Top-ranked genes were subsequently applied to validate their associations with obesity-related traits in three independent in-house GWAS samples.
resultsWe identified RAD21 and EZH2 as over-represented, and STAT2 (signal transducer and activator of transcription 2) and IRF3 (interferon regulatory transcription factor 3) as depleted transcription factors. Histone modification of H3K9me3 and chromatin state segmentation of 'poised promoter' and 'repressed' were over-represented. All genes were prioritized and we selected the top five genes for validation at the population level. Combining results from the three GWAS samples, rs7522101 in ESRRG (estrogen-related receptor-γ) remained significantly associated with body mass index after multiple testing corrections (P=7.25 × 10(-5)). It was also associated with β-cell function (P=1.99 × 10(-3)) and fasting glucose level (P<0.05) in the meta-analyses of glucose and insulin-related traits consortium (MAGIC) data set.Cnoclusions:In summary, we identified epigenomic characteristics for obesity genes and suggested ESRRG as a novel obesity-susceptibility gene.
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