Evidence map›Paper›PMID 27113407›Full record

ReviewPharmacology & therapeutics2016

Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis.

Sathish Sivaprakasam, Puttur D Prasad, Nagendra Singh

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pharmacology & therapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 295 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
295citing papers in PubMed, 5 pooled it
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

295 citing papers in PubMed, 5 syntheses or guidelines pooled it, 552 citations in OpenAlex.

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  20. Biomolecules · 2026
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235 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Sathish SivaprakasamDepartment of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, Georgia 30912, USA.
Puttur D PrasadDepartment of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, Georgia 30912, USA.
Nagendra SinghDepartment of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, Georgia 30912, USA; Cancer Research Center, Augusta University, Augusta, Georgia 30912, USA. Electronic address: nasingh@gru.edu.
Augusta University · USAugusta University Health · US

Funding

Regulation of colonic inflammation by butyrate/niacin receptor Gpr109aR01DK103576 · NIDDK · AUGUSTA UNIVERSITY · PI SINGH, NAGENDRA · 2014 to 2017
$1.3M
Expansion of alloantigen reactive Tregs for transplantation toleranceR21AI085440 · NIAID · AUGUSTA UNIVERSITY · PI SINGH, NAGENDRA · 2010 to 2011
$402k
NIAID NIH HHS R21 AI085440NIDDK NIH HHS R01 DK103576
6 · The paper itself

Abstract

Epidemiological studies have linked increased incidence of inflammatory diseases and intestinal cancers in the developed parts of the world to the consumption of diets poor in dietary fibers and rich in refined carbohydrates. Gut bacteria residing in the intestinal lumen exclusively metabolize dietary fibers. Butyrate, propionate and acetate, which are collectively called short-chain fatty acids (SCFAs), are generated by fermentation of dietary fibers by gut microbiota. Evidences indicate that SCFAs are key players in regulating beneficial effect of dietary fibers and gut microbiota on our health. SCFAs interact with metabolite-sensing G protein-coupled receptors GPR41, GPR43 and GPR109A expressed in gut epithelium and immune cells. These interactions induce mechanisms that play a key role in maintaining homeostasis in gut and other organs. This review summarizes the protective roles of GPR41, GPR43 and GPR109A in dietary fibers-, gut microbiota- and SCFAs-mediated suppression of inflammation and carcinogenesis in gut and other organs.

Indexed as

AcetatesAnimalsButyratesCarcinogenesisDietary FiberFatty Acids, VolatileGastrointestinal MicrobiomeHumansInflammationIntestinal NeoplasmsPropionatesReceptors, Cell SurfaceReceptors, G-Protein-CoupledReceptors, NicotinicAcetatesButyratesDietary FiberFatty Acids, VolatileFFAR2 protein, humanFFAR3 protein, humanHCAR2 protein, humanPropionatesReceptors, Cell SurfaceReceptors, G-Protein-CoupledReceptors, NicotinicDietary fibersGut microbiotaInflammation and cancerShort-chain fatty acid receptorsShort-chain fatty acids

Identifiers

PMID27113407
PMCPMC4942363
OpenAlexW2344885638

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.