ArticleThe Journal of pediatrics2016
Early Heart Rate Characteristics Predict Death and Morbidities in Preterm Infants.
Article in The Journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Prediction Models for Bronchopulmonary Dysplasia in Preterm Infants: A Systematic Review.Frontiers in pediatrics · 2022Pooled it
- Comparing mortality risk models in VLBW and preterm infants: systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2020Pooled it
- Temporal trends in heart rate characteristic index preceding necrotizing enterocolitis in preterm infants.Journal of neonatal-perinatal medicine · 2026Article
- Prediction of bronchopulmonary dysplasia seven days after birth using respiratory and oxygenation timeseries with machine learning.Pediatric research · 2026Article
- Reduced heart rate variability predicts severe intraventricular haemorrhage in extremely preterm infants.Pediatric research · 2026Article
- Predicting Dexamethasone-Associated Extubation Success in Preterm Infants.American journal of perinatology · 2026Article
- Postnatal Steroids in Preterm Infants: A Narrative Review Series-Part 2: Cardiovascular Impacts.Children (Basel, Switzerland) · 2026Review
- A Clinically Oriented Framework for Real-Time Heart Rate Variability Analysis: A Novel Approach To Personalized and Robust Monitoring.Journal of medical systems · 2026Article
- Using heart rate variability to predict neurological outcomes in preterm infants: a scoping review.Pediatric research · 2025Article
- Heart rate patterns predicting cerebral palsy in preterm infants.Pediatric research · 2025Article
- Is the P-wave dispersion a valuable tool in determining the atrial arrhythmia of newborn babies with sepsis?Northern clinics of Istanbul · 2025Article
- Association of Heart Rate Variability with Postnatal Maturation in Preterm Infants.Neonatology · 2025Article
- Heart rate characteristics predict risk of mortality in preterm infants in low and high target oxygen saturation ranges.ERJ open research · 2024Article
- Sample entropy correlates with intraventricular hemorrhage and mortality in premature infants early in life.Pediatric research · 2024Article
- Highly comparative time series analysis of oxygen saturation and heart rate to predict respiratory outcomes in extremely preterm infants.Physiological measurement · 2024Observational
- Framework for Considering Abnormal Heart Rate Characteristics and Other Signs of Sepsis in Very Low Birth Weight Infants.American journal of perinatology · 2024Article
- Maturation of cardioventilatory physiological trajectories in extremely preterm infants.Pediatric research · 2024Article
- The Finnegan Score for Neonatal Opioid Withdrawal Revisited With Routine Electronic Data: Retrospective Study.JMIR pediatrics and parenting · 2024Article
- Transforming neonatal care with artificial intelligence: challenges, ethical consideration, and opportunities.Journal of perinatology : official journal of the California Perinatal Association · 2024Review
- Early Vital Sign Differences in Very Low Birth Weight Infants with Severe Intraventricular Hemorrhage.American journal of perinatology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo determine whether an early heart rate characteristics (HRC) index (HeRO score), measured in the first day and week after birth predicts death and morbidities compared with established illness severity scores. STUDY
designFor all very low birth weight infants in a single neonatal intensive care unit from 2004-2014, the average first day HRC index was calculated within 24 hours of birth (aHRC-24h) and the average first week HRC index within 7 days of birth (aHRC-7d). The Score for Neonatal Acute Physiology (SNAP-II) and Clinical Risk Indicator for Babies (CRIB-II) were calculated when data were available. The aHRC was compared with the SNAP-II and CRIB-II for predicting death, late-onset septicemia, necrotizing enterocolitis, bronchopulmonary dysplasia, severe intraventricular hemorrhage, or severe retinopathy of prematurity.
resultsAll 4 scores were associated with death and severe intraventricular hemorrhage (P < .01). The OR and 95% CI for every 1-point increase in aHRC for predicting mortality, adjusted for gestational age, was 1.59 (1.25-2.00) for aHRC-24h and 2.61 (1.58-4.33) for aHRC-7d. High aHRC-7d, SNAP-II, and CRIB-II were associated with bronchopulmonary dysplasia (P < .001). High aHRC-7d was associated with late-onset septicemia (P < .05). None of the scores predicted necrotizing enterocolitis or severe retinopathy of prematurity.
conclusionsHRC assessed in the first day or first week after birth compares favorably to established risk scores to predict death and morbidities in very low birth weight infants.
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Registered trials
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