Evidence map›Paper›PMID 27113373›Full record

SynthesisLung2016

Inflammatory Mediators and Oxidative Stress in Animals Subjected to Smoke Inhalation: A Systematic Review.

Fernanda Oliveira de Carvalho, Fernanda Araújo Felipe, Aida Carla Santana de Melo Costa, Luciana Garcez Barretto Teixeira, Érika Ramos Silva, Paula Santos Nunes, Saravanan Shanmugam, Waldecy de Lucca Junior, Jullyana S S Quintans, Adriano Antunes de Souza Araújo

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Lung, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Mechanism of Phosgene-Induced Acute Lung Injury and Treatment Strategy.International journal of molecular sciences · 2021
    Review
  11. Article
  12. Second-hand smoke and NFE2L2 genotype interaction increases paediatric asthma risk and severity.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021
    Article
  13. Edaravone attenuates smoke inhalation injury in rats by the Notch pathway.American journal of translational research · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Smoke Inhalation Injury: Etiopathogenesis, Diagnosis, and Management.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2018
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fernanda Oliveira de CarvalhoNúcleo de Pós-Graduação em Medicina da Universidade Federal de Sergipe-UFS, Rua Cláudio Batista S/N Bairro Sanatório, Aracaju, SE, CEP 49.100-000, Brazil.
Fernanda Araújo FelipeNúcleo de Pós-Graduação em Medicina da Universidade Federal de Sergipe-UFS, Rua Cláudio Batista S/N Bairro Sanatório, Aracaju, SE, CEP 49.100-000, Brazil.
Aida Carla Santana de Melo CostaNúcleo de Pós-Graduação em Medicina da Universidade Federal de Sergipe-UFS, Rua Cláudio Batista S/N Bairro Sanatório, Aracaju, SE, CEP 49.100-000, Brazil.
Luciana Garcez Barretto TeixeiraNúcleo de Pós-Graduação em Medicina da Universidade Federal de Sergipe-UFS, Rua Cláudio Batista S/N Bairro Sanatório, Aracaju, SE, CEP 49.100-000, Brazil.
Érika Ramos SilvaNúcleo de Pós-Graduação em Medicina da Universidade Federal de Sergipe-UFS, Rua Cláudio Batista S/N Bairro Sanatório, Aracaju, SE, CEP 49.100-000, Brazil.
Paula Santos NunesNúcleo de Pós-Graduação em Medicina da Universidade Federal de Sergipe-UFS, Rua Cláudio Batista S/N Bairro Sanatório, Aracaju, SE, CEP 49.100-000, Brazil.
Saravanan ShanmugamNúcleo de Pós-Graduação em Medicina da Universidade Federal de Sergipe-UFS, Rua Cláudio Batista S/N Bairro Sanatório, Aracaju, SE, CEP 49.100-000, Brazil.
Waldecy de Lucca JuniorNúcleo de Pós-Graduação em Medicina da Universidade Federal de Sergipe-UFS, Rua Cláudio Batista S/N Bairro Sanatório, Aracaju, SE, CEP 49.100-000, Brazil.
Jullyana S S QuintansNúcleo de Pós-Graduação em Medicina da Universidade Federal de Sergipe-UFS, Rua Cláudio Batista S/N Bairro Sanatório, Aracaju, SE, CEP 49.100-000, Brazil.
Adriano Antunes de Souza AraújoNúcleo de Pós-Graduação em Medicina da Universidade Federal de Sergipe-UFS, Rua Cláudio Batista S/N Bairro Sanatório, Aracaju, SE, CEP 49.100-000, Brazil. adriasa2001@yahoo.com.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe inhalation injury is usually initiated by uninhibited absorption of smoke, favoring the release of cytokines and other lipid mediators from inflammatory cells in lung airways and parenchyma.

objectivesTo systematically review, examine, and synthesize the main inflammatory mediators analyzed in published studies in animals subjected to smoke inhalation, as well as oxidative stress. SEARCH STRATEGY: A comprehensive literature search was conducted through MEDLINE-PubMed, Web of Science, and Scopus. SELECTION CRITERIA: Studies with animals subjected to lung damage from smoke inhalation that evaluated the presence and the action of inflammatory mediators and oxidative stress.

resultsA total of 1332 studies were initially identified, with only 31 meeting the inclusion criteria. The inflammatory mediators and oxidative stress markers studied and presented in the articles described herein were varied; however, the most cited ones were tumor necrosis factor-alpha (6), IL-8 and IL-6 (both studied in five articles), IL-1β and nuclear factor kappa β (both studied in 4 articles), malondialdehyde (11 studies), and myeloperoxidase (7). It is worth noting that most studies evaluated more than one inflammatory mediator and oxidative stress marker.

conclusionBased on this review, we could observe that the main inflammatory mediators and oxidative stress markers analyzed were TNF-α, IL-8, IL-6, IL-1β, nuclear factor kappa β, MDA, and MPO. However, it is necessary to increase the rigor of study design and data, in order to have studies that are more homogeneous and with appropriate methodological quality.

Indexed as

Oxidative StressAnimalsBiomarkersCytokinesInflammationInflammation MediatorsInterleukin-1betaInterleukin-6Interleukin-8MalondialdehydeNF-kappa BPeroxidaseSmoke Inhalation InjuryTumor Necrosis Factor-alphaBiomarkersCytokinesInflammation MediatorsInterleukin-1betaInterleukin-6Interleukin-8MalondialdehydeNF-kappa BPeroxidaseTumor Necrosis Factor-alphaCytokineInflammatory mediatorOxidative stressPulmonary injurySmoke inhalation

Identifiers

PMID27113373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.