Evidence map›Paper›PMID 27113266›Full record

ArticleJournal of pediatric surgery2016

Thyroidectomy for Graves' disease in children: Indications and complications.

Dawn M Elfenbein, Micah Katz, David F Schneider, Herbert Chen, Rebecca S Sippel

Abstract read
In one paragraph

Article in Journal of pediatric surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Radioiodine or thyroidectomy in children and adolescents with Graves' disease: a structured literature review of efficacy and safety.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2026
    Review
  3. Article
  4. Pediatric Graves' Disease: Surgical Interventions in a Single Institution - A Comprehensive Case Series.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024
    Article
  5. Article
  6. Graves' Disease in Children: An Update.Clinical medicine insights. Endocrinology and diabetes · 2023
    Review
  7. Article
  8. Article
  9. Hyperthyroidism in adolescents.Endocrine connections · 2021
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dawn M ElfenbeinUniversity of Wisconsin, Department of Surgery, Section of Endocrine Surgery, 600 Highland Ave, K4/739, Madison, WI 53792. Electronic address: delfenbe@uci.edu.
Micah KatzUniversity of Wisconsin, Department of Surgery, Section of Endocrine Surgery, 600 Highland Ave, K4/739, Madison, WI 53792.
David F SchneiderUniversity of Wisconsin, Department of Surgery, Section of Endocrine Surgery, 600 Highland Ave, K4/739, Madison, WI 53792.
Herbert ChenUniversity of Wisconsin, Department of Surgery, Section of Endocrine Surgery, 600 Highland Ave, K4/739, Madison, WI 53792.
Rebecca S SippelUniversity of Wisconsin, Department of Surgery, Section of Endocrine Surgery, 600 Highland Ave, K4/739, Madison, WI 53792.

Funding

Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Institutional Clinical and Translational Science AwardKL2TR000428 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$6.2M
NCATS NIH HHS KL2 TR000428NCATS NIH HHS UL1 TR000427
6 · The paper itself

Abstract

backgroundThe utilization of thyroidectomy for Graves' disease remains controversial; we aim to evaluate the indications for and complications of thyroidectomy for Graves' in children.

methodsA retrospective analysis was performed on all Graves' patients who underwent thyroidectomy from 2009 to 2013 at a high volume academic center. Pediatric patients were <18years old, and a comparative analysis of indications for surgery and complications was performed.

results167 patients underwent thyroidectomy: 31 pediatric patients and 136 adults. Failure of antithyroid medications was the indication for surgery in 55% of the children vs 36% of adults (p=0.05). Mean duration of medications prior to surgery was similar. No children had failed RAI therapy prior to surgery, but 12.5% of the adult population had (p=0.04). Surgical outcomes were similar.

conclusionClinicians may be more likely to refer children who fail medical treatment to surgery over RAI. Thyroidectomy at a high volume hospital should be discussed as a treatment option for children with Graves'.

Indexed as

ThyroidectomyAdolescentAdultAge FactorsChildChild, PreschoolFemaleGraves DiseaseHospitals, High-VolumeHumansMaleMiddle AgedPostoperative ComplicationsRetrospective StudiesTreatment OutcomeYoung AdultPediatric Graves' diseasePediatric hyperthyroidismShared decision makingThyroidectomy

Identifiers

PMID27113266
PMCPMC5039045

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.