Evidence map›Paper›PMID 27113131›Full record

ArticleJournal of anatomy2016

Distribution of proteins within different compartments of tendon varies according to tendon type.

Chavaunne T Thorpe, Kabelan J Karunaseelan, Jade Ng Chieng Hin, Graham P Riley, Helen L Birch, Peter D Clegg, Hazel R C Screen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of anatomy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Viable tendon neotissue from adult adipose-derived multipotent stromal cells.Frontiers in bioengineering and biotechnology · 2023
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Elastic fibers in orthopedics: Form and function in tendons and ligaments, clinical implications, and future directions.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Chavaunne T ThorpeInstitute of Bioengineering, School of Engineering and Materials Science, Queen Mary University of London, London, UK.
Kabelan J KarunaseelanInstitute of Bioengineering, School of Engineering and Materials Science, Queen Mary University of London, London, UK.
Jade Ng Chieng HinInstitute of Bioengineering, School of Engineering and Materials Science, Queen Mary University of London, London, UK.
Graham P RileySchool of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, UK.
Helen L BirchInstitute of Orthopaedics and Musculoskeletal Science, University College London, Royal National Orthopaedic Hospital, Stanmore, UK.
Peter D CleggDepartment of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Neston, UK.
Hazel R C ScreenInstitute of Bioengineering, School of Engineering and Materials Science, Queen Mary University of London, London, UK.
Queen Mary University of London · GBRoyal National Orthopaedic Hospital · GBUniversity of East Anglia · GBUniversity of Liverpool · GB

Funding

Medical Research Council MR/K006312/1
6 · The paper itself

Abstract

Although the predominant function of all tendons is to transfer force from muscle to bone and position the limbs, some tendons additionally function as energy stores, reducing the energetic cost of locomotion. To maximise energy storage and return, energy-storing tendons need to be more extensible and elastic than tendons with a purely positional function. These properties are conferred in part by a specialisation of a specific compartment of the tendon, the interfascicular matrix, which enables sliding and recoil between adjacent fascicles. However, the composition of the interfascicular matrix is poorly characterised and we therefore tested the hypothesis that the distribution of elastin and proteoglycans differs between energy-storing and positional tendons, and that protein distribution varies between the fascicular matrix and the interfascicular matrix, with localisation of elastin and lubricin to the interfascicular matrix. Protein distribution in the energy-storing equine superficial digital flexor tendon and positional common digital extensor tendon was assessed using histology and immunohistochemistry. The results support the hypothesis, demonstrating enrichment of lubricin in the interfascicular matrix in both tendon types, where it is likely to facilitate interfascicular sliding. Elastin was also localised to the interfascicular matrix, specifically in the energy-storing superficial digital flexor tendon, which may account for the greater elasticity of the interfascicular matrix in this tendon. A differential distribution of proteoglycans was identified between tendon types and regions, which may indicate a distinct role for each of these proteins in tendon. These data provide important advances into fully characterising structure-function relationships within tendon.

Indexed as

AnimalsElastinGlycoproteinsHorsesImage Processing, Computer-AssistedImmunohistochemistryProteoglycan 4TendonsElastinGlycoproteinsProteoglycan 4endotenonhistologyimmunohistochemistryinterfascicular matrixproteoglycans

Identifiers

PMID27113131
PMCPMC4974547
OpenAlexW2344409261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.