Evidence map›Paper›PMID 27113076›Full record

ArticleThe journal of headache and pain2016

Quantitative neuromagnetic signatures of aberrant cortical excitability in pediatric chronic migraine.

Kimberly A Leiken, Jing Xiang, Emily Curry, Hisako Fujiwara, Douglas F Rose, Janelle R Allen, Joanne E Kacperski, Hope L O'Brien, Marielle A Kabbouche, Scott W Powers and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of headache and pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00600717 (Localizing Functional Brain Cortices and Epileptogenic Zones With High Frequency Brain Signals), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00600717 withdrawnnot on this map

Localizing Functional Brain Cortices and Epileptogenic Zones With High Frequency Brain Signals

TypeobservationalSponsorChildren's Hospital Medical Center, CincinnatiRan2000 to 2027Enrolled0ConditionsEpilepsy, Migraine, Headache, Pain
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Does the migraine attack start in the cortex and is the cortex critical in the migraine process?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kimberly A LeikenDivision of Neurology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 2015, Cincinnati, OH, 45220, USA. Kimberly.leiken@cchmc.org.
Jing XiangDivision of Neurology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 2015, Cincinnati, OH, 45220, USA.
Emily CurryDivision of Neurology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 2015, Cincinnati, OH, 45220, USA.
Hisako FujiwaraDivision of Neurology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 2015, Cincinnati, OH, 45220, USA.
Douglas F RoseDivision of Neurology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 2015, Cincinnati, OH, 45220, USA.
Janelle R AllenDivision of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Joanne E KacperskiDivision of Neurology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 2015, Cincinnati, OH, 45220, USA.
Hope L O'BrienDivision of Neurology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 2015, Cincinnati, OH, 45220, USA.
Marielle A KabboucheDivision of Neurology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 2015, Cincinnati, OH, 45220, USA.
Scott W PowersDepartment of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH, USA.
Andrew D HersheyDivision of Neurology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 2015, Cincinnati, OH, 45220, USA.

Funding

Aberrant Neuromagnetic Signatures with Chronic MigraineR21NS081420 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI XIANG, JING · 2013 to 2014
$398k
Motor cortex dysfunction in migraineR21NS072817 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI XIANG, JING · 2010 to 2011
$356k
NINDS NIH HHS 1R21NS081420NINDS NIH HHS R21 NS072817NINDS NIH HHS R21NS072817NINDS NIH HHS R21 NS081420
6 · The paper itself

Abstract

backgroundReports have suggested that abnormal cortical excitability may be associated with acute migraines. The present study quantitatively assesses the degree of cortical excitability in chronic migraine as compared to acute migraine and healthy controls within the pediatric population.

methodsWe investigated 27 children suffering from chronic migraine, 27 children suffering from acute migraine, and 27 healthy controls using a magnetoencephalography (MEG) system, recording at a sampling rate of 6000 Hz. All groups were age-matched and gender-matched. Neuromagnetic brain activation was elicited by a finger-tapping motor task. The spatiotemporal and spectral signatures of MEG data within a 5-2884 Hz range were analyzed using Morlet wavelet transform and beamformer analyses.

resultsCompared with controls, the chronic migraine group showed (1) significantly prolonged latencies of movement-elicited magnetic fields (MEFs) between 5 and 100 Hz; (2) increased spectral power between 100 and 200 Hz, and between 2200 and 2800 Hz; and (3) a higher likelihood of neuromagnetic activation in the ipsilateral sensorimotor cortices, supplementary motor area, and occipital regions. Compared with acute migraine group, chronic migraine patients showed (1) significantly higher odds of having strong MEFs after 150 ms; and (2) significantly higher odds of having neuromagnetic activation from the deep brain areas.

conclusionsResults demonstrated that chronic migraine subjects were not only different from the healthy controls, but also different from acute migraine subjects. The chronification of migraines may be associated with elevated cortical excitability, delayed and spread neural response, as well as aberrant activation from deep brain areas.

Indexed as

MagnetoencephalographyAdolescentCase-Control StudiesCerebral CortexChildChronic DiseaseFemaleHumansMaleMigraine DisordersOccipital LobeSensorimotor CortexUnited StatesDeep brain sourcesHigh frequency oscillationsMagnetoencephalography (MEG)MigrainePediatricWavelet transform

Identifiers

PMID27113076
PMCPMC4844586

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.