ArticleHypertension (Dallas, Tex. : 1979)2016
Circulating Antiangiogenic Factors and Myocardial Dysfunction in Hypertensive Disorders of Pregnancy.
Registry-linked trialAbstract read
In one paragraph
Article in Hypertension (Dallas, Tex. : 1979), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07606027 (Postpartum Remote Monitoring and Integration of Mobile Health With Engagement From Community Health Workers for Regulating Elevated Blood Pressure), which is not on this map. Cited by 34 papers.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
8.7field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Postpartum Remote Monitoring and Integration of Mobile Health With Engagement From Community Health Workers for Regulating Elevated Blood Pressure
Who cites it
34 citing papers in PubMed, 78 citations in OpenAlex.
- Obstetric History Versus Biomarkers: Hypertension Risk Up to 15 Years Postpartum.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Multi-omic insights of preeclampsia and cardiovascular health outcomes.Communications medicine · 2025Review
- Long-Term Cardiovascular Risk and Maternal History of Pre-Eclampsia.Journal of clinical medicine · 2025Review
- Advances in Our Understanding of Cardiovascular Diseases After Preeclampsia.Circulation research · 2025Review
- Maternal and fetal outcomes in those with autoimmune connective tissue disease.Clinical rheumatology · 2025Article
- Coronary Microvascular Function Following Severe Preeclampsia.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Pathophysiology of Preeclampsia-Induced Vascular Dysfunction and Implications for Subclinical Myocardial Damage and Heart Failure.JACC. Advances · 2024Review
- Coronary Microvascular Function Following Severe Preeclampsia.medRxiv : the preprint server for health sciences · 2024Article
- The Importance of Inflammatory and Angiogenic Markers in the Evaluation of Early Cardiovascular Disease Risk in Women with Hypertensive Disorders of Pregnancy.Journal of cardiovascular development and disease · 2023Review
- Incidence of Heart Failure Related to Co-Occurrence of Gestational Hypertensive Disorders and Gestational Diabetes.JACC. Advances · 2023Article
- Prevalence of pre-eclampsia and adverse pregnancy outcomes in women with pre-existing cardiomyopathy: a multi-centre retrospective cohort study.Scientific reports · 2023Article
- Animal Models of Cardiovascular Complications of Pregnancy.Circulation research · 2022Review
- Article
- Imbalances in circulating angiogenic factors in the pathophysiology of preeclampsia and related disorders.American journal of obstetrics and gynecology · 2022Review
- Blood-pressure variability is associated with left-ventricular mechanics in patients with gestational hypertension and preeclampsia.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Irisin Protects the Human Placenta from Oxidative Stress and Apoptosis via Activation of the Akt Signaling Pathway.International journal of molecular sciences · 2021Article
- Long-Term Cardiovascular Disease Risk in Women After Hypertensive Disorders of Pregnancy: Recent Advances in Hypertension.Hypertension (Dallas, Tex. : 1979) · 2021Review
- Induction of the PPARγ (Peroxisome Proliferator-Activated Receptor γ)-GCM1 (Glial Cell Missing 1) Syncytialization Axis Reduces sFLT1 (Soluble fms-Like Tyrosine Kinase 1) in the Preeclamptic Placenta.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Association of Hypertensive Disorders of Pregnancy With Left Ventricular Remodeling Later in Life.Journal of the American College of Cardiology · 2021Article
- Long-Term Postpartum Cardiac Function and Its Association With Preeclampsia.Journal of the American Heart Association · 2021Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 1 country.
Sajid ShahulFrom the Department of Anesthesia and Critical Care (S.S., J.N., A.T.), Section of Cardiology, Department of Medicine (D.M., R.M.L.), and Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology (S.R.), University of Chicago, IL; Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (J.B.W., R.T.); Center for Humanizing Critical Care, Intermountain Healthcare, Department of Medicine, University of Utah, Salt Lake City (S.M.B.); Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA (S.B., S.A.K., S.R.); Center for Vascular Biology, Department of Medicine (S.S., S.A.K.) and Department of Anesthesia, Critical Care and Pain Medicine (A.M., D.T.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; and Department of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia (Z.A.). sshahul1@dacc.uchicago.edu.
Diego MedvedofskyFrom the Department of Anesthesia and Critical Care (S.S., J.N., A.T.), Section of Cardiology, Department of Medicine (D.M., R.M.L.), and Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology (S.R.), University of Chicago, IL; Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (J.B.W., R.T.); Center for Humanizing Critical Care, Intermountain Healthcare, Department of Medicine, University of Utah, Salt Lake City (S.M.B.); Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA (S.B., S.A.K., S.R.); Center for Vascular Biology, Department of Medicine (S.S., S.A.K.) and Department of Anesthesia, Critical Care and Pain Medicine (A.M., D.T.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; and Department of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia (Z.A.).
Julia B WengerFrom the Department of Anesthesia and Critical Care (S.S., J.N., A.T.), Section of Cardiology, Department of Medicine (D.M., R.M.L.), and Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology (S.R.), University of Chicago, IL; Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (J.B.W., R.T.); Center for Humanizing Critical Care, Intermountain Healthcare, Department of Medicine, University of Utah, Salt Lake City (S.M.B.); Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA (S.B., S.A.K., S.R.); Center for Vascular Biology, Department of Medicine (S.S., S.A.K.) and Department of Anesthesia, Critical Care and Pain Medicine (A.M., D.T.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; and Department of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia (Z.A.).
Junaid NizamuddinFrom the Department of Anesthesia and Critical Care (S.S., J.N., A.T.), Section of Cardiology, Department of Medicine (D.M., R.M.L.), and Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology (S.R.), University of Chicago, IL; Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (J.B.W., R.T.); Center for Humanizing Critical Care, Intermountain Healthcare, Department of Medicine, University of Utah, Salt Lake City (S.M.B.); Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA (S.B., S.A.K., S.R.); Center for Vascular Biology, Department of Medicine (S.S., S.A.K.) and Department of Anesthesia, Critical Care and Pain Medicine (A.M., D.T.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; and Department of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia (Z.A.).
Samuel M BrownFrom the Department of Anesthesia and Critical Care (S.S., J.N., A.T.), Section of Cardiology, Department of Medicine (D.M., R.M.L.), and Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology (S.R.), University of Chicago, IL; Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (J.B.W., R.T.); Center for Humanizing Critical Care, Intermountain Healthcare, Department of Medicine, University of Utah, Salt Lake City (S.M.B.); Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA (S.B., S.A.K., S.R.); Center for Vascular Biology, Department of Medicine (S.S., S.A.K.) and Department of Anesthesia, Critical Care and Pain Medicine (A.M., D.T.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; and Department of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia (Z.A.).
Surichhya BajracharyaFrom the Department of Anesthesia and Critical Care (S.S., J.N., A.T.), Section of Cardiology, Department of Medicine (D.M., R.M.L.), and Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology (S.R.), University of Chicago, IL; Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (J.B.W., R.T.); Center for Humanizing Critical Care, Intermountain Healthcare, Department of Medicine, University of Utah, Salt Lake City (S.M.B.); Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA (S.B., S.A.K., S.R.); Center for Vascular Biology, Department of Medicine (S.S., S.A.K.) and Department of Anesthesia, Critical Care and Pain Medicine (A.M., D.T.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; and Department of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia (Z.A.).
Saira SalahuddinFrom the Department of Anesthesia and Critical Care (S.S., J.N., A.T.), Section of Cardiology, Department of Medicine (D.M., R.M.L.), and Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology (S.R.), University of Chicago, IL; Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (J.B.W., R.T.); Center for Humanizing Critical Care, Intermountain Healthcare, Department of Medicine, University of Utah, Salt Lake City (S.M.B.); Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA (S.B., S.A.K., S.R.); Center for Vascular Biology, Department of Medicine (S.S., S.A.K.) and Department of Anesthesia, Critical Care and Pain Medicine (A.M., D.T.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; and Department of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia (Z.A.).
Ravi ThadhaniFrom the Department of Anesthesia and Critical Care (S.S., J.N., A.T.), Section of Cardiology, Department of Medicine (D.M., R.M.L.), and Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology (S.R.), University of Chicago, IL; Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (J.B.W., R.T.); Center for Humanizing Critical Care, Intermountain Healthcare, Department of Medicine, University of Utah, Salt Lake City (S.M.B.); Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA (S.B., S.A.K., S.R.); Center for Vascular Biology, Department of Medicine (S.S., S.A.K.) and Department of Anesthesia, Critical Care and Pain Medicine (A.M., D.T.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; and Department of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia (Z.A.).
Ariel MuellerFrom the Department of Anesthesia and Critical Care (S.S., J.N., A.T.), Section of Cardiology, Department of Medicine (D.M., R.M.L.), and Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology (S.R.), University of Chicago, IL; Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (J.B.W., R.T.); Center for Humanizing Critical Care, Intermountain Healthcare, Department of Medicine, University of Utah, Salt Lake City (S.M.B.); Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA (S.B., S.A.K., S.R.); Center for Vascular Biology, Department of Medicine (S.S., S.A.K.) and Department of Anesthesia, Critical Care and Pain Medicine (A.M., D.T.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; and Department of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia (Z.A.).
Avery TungFrom the Department of Anesthesia and Critical Care (S.S., J.N., A.T.), Section of Cardiology, Department of Medicine (D.M., R.M.L.), and Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology (S.R.), University of Chicago, IL; Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (J.B.W., R.T.); Center for Humanizing Critical Care, Intermountain Healthcare, Department of Medicine, University of Utah, Salt Lake City (S.M.B.); Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA (S.B., S.A.K., S.R.); Center for Vascular Biology, Department of Medicine (S.S., S.A.K.) and Department of Anesthesia, Critical Care and Pain Medicine (A.M., D.T.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; and Department of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia (Z.A.).
Roberto M LangFrom the Department of Anesthesia and Critical Care (S.S., J.N., A.T.), Section of Cardiology, Department of Medicine (D.M., R.M.L.), and Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology (S.R.), University of Chicago, IL; Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (J.B.W., R.T.); Center for Humanizing Critical Care, Intermountain Healthcare, Department of Medicine, University of Utah, Salt Lake City (S.M.B.); Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA (S.B., S.A.K., S.R.); Center for Vascular Biology, Department of Medicine (S.S., S.A.K.) and Department of Anesthesia, Critical Care and Pain Medicine (A.M., D.T.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; and Department of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia (Z.A.).
Zoltan AranyFrom the Department of Anesthesia and Critical Care (S.S., J.N., A.T.), Section of Cardiology, Department of Medicine (D.M., R.M.L.), and Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology (S.R.), University of Chicago, IL; Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (J.B.W., R.T.); Center for Humanizing Critical Care, Intermountain Healthcare, Department of Medicine, University of Utah, Salt Lake City (S.M.B.); Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA (S.B., S.A.K., S.R.); Center for Vascular Biology, Department of Medicine (S.S., S.A.K.) and Department of Anesthesia, Critical Care and Pain Medicine (A.M., D.T.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; and Department of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia (Z.A.).
Daniel TalmorFrom the Department of Anesthesia and Critical Care (S.S., J.N., A.T.), Section of Cardiology, Department of Medicine (D.M., R.M.L.), and Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology (S.R.), University of Chicago, IL; Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (J.B.W., R.T.); Center for Humanizing Critical Care, Intermountain Healthcare, Department of Medicine, University of Utah, Salt Lake City (S.M.B.); Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA (S.B., S.A.K., S.R.); Center for Vascular Biology, Department of Medicine (S.S., S.A.K.) and Department of Anesthesia, Critical Care and Pain Medicine (A.M., D.T.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; and Department of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia (Z.A.).
S Ananth KarumanchiFrom the Department of Anesthesia and Critical Care (S.S., J.N., A.T.), Section of Cardiology, Department of Medicine (D.M., R.M.L.), and Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology (S.R.), University of Chicago, IL; Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (J.B.W., R.T.); Center for Humanizing Critical Care, Intermountain Healthcare, Department of Medicine, University of Utah, Salt Lake City (S.M.B.); Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA (S.B., S.A.K., S.R.); Center for Vascular Biology, Department of Medicine (S.S., S.A.K.) and Department of Anesthesia, Critical Care and Pain Medicine (A.M., D.T.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; and Department of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia (Z.A.).
Sarosh RanaFrom the Department of Anesthesia and Critical Care (S.S., J.N., A.T.), Section of Cardiology, Department of Medicine (D.M., R.M.L.), and Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology (S.R.), University of Chicago, IL; Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (J.B.W., R.T.); Center for Humanizing Critical Care, Intermountain Healthcare, Department of Medicine, University of Utah, Salt Lake City (S.M.B.); Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA (S.B., S.A.K., S.R.); Center for Vascular Biology, Department of Medicine (S.S., S.A.K.) and Department of Anesthesia, Critical Care and Pain Medicine (A.M., D.T.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; and Department of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia (Z.A.).
Beth Israel Deaconess Medical Center · USUniversity of Utah · USIntermountain Healthcare · USHarvard University · USMassachusetts General Hospital · US
Funding
Howard Hughes Medical Institute
Abstract
Hypertensive disorders of pregnancy (HDP) are associated with subclinical changes in cardiac function. Although the mechanism underlying this finding is unknown, elevated levels of soluble antiangiogenic proteins such as soluble fms-like tyrosine kinase-1 (sFlt1) and soluble endoglin (sEng) are associated with myocardial dysfunction and may play a role. We hypothesized that these antiangiogenic proteins may contribute to the development of cardiac dysfunction in HDP. We prospectively studied 207 pregnant women with HDP and nonhypertensive controls and evaluated whether changes in global longitudinal strain (GLS) observed on echocardiography is specific for HDP and whether these changes correlate with HDP biomarkers, sFlt1 and sEng. A total of 62 (30%) patients were diagnosed with preeclampsia (group A), 105 (51%) did not have an HDP (group B), and 40 (19%) were diagnosed with chronic or gestational hypertension (group C). Blood was drawn and sFlt1 and sEng levels measured using enzyme-linked immunosorbent assay. Comprehensive echocardiograms, including measurement of GLS, were performed on all patients. Overall, GLS was worse in women in group A (preeclampsia) than those in group B or C. Increasing sFlt1 and sEng levels correlated with worsening GLS (r=0.44 for sFlt1 and r=0.46 for sEng, both P<0.001), which remained significant after multivariable analysis (r=0.18 and r=0.22, both P≤0.01). Increasing levels also correlated with increasing left ventricular mass index, which also remained significant after multivariable analysis (r=0.20 for sFlt1 and 0.19 for sEng, both P=0.01). Elevated circulating levels of antiangiogenic proteins in HDP correlate with and may contribute to myocardial dysfunction as measured by GLS.
Indexed as
AdultAngiogenic ProteinsBiomarkersCase-Control StudiesEnzyme-Linked Immunosorbent AssayFemaleGestational AgeHumansHypertension, Pregnancy-InducedPre-EclampsiaPregnancyPregnancy OutcomeProspective StudiesSensitivity and SpecificityAngiogenic ProteinsBiomarkersbiomarkersechocardiographyhypertensionpreeclampsiapregnancy
Identifiers
What OpenQuestion holds
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Registered trials
NCT07606027ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.