ArticleScientific reports2016
Genome-wide non-CpG methylation of the host genome during M. tuberculosis infection.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 66 citations in OpenAlex.
- Epigenetic Reprogramming byAntibiotics (Basel, Switzerland) · 2026Review
- Hijacked epigenomes: how bacterial effectors rewrite host gene expression.Archives of microbiology · 2026Review
- Macrophage states and polarization duringFrontiers in cellular and infection microbiology · 2026Review
- The pathway of autophagy in the epigenetic landscape ofAutophagy · 2025Review
- METTL14 mediates the m6A methylation of miR-29a-3p, thereby activating the MAP2K6 signaling pathway and exacerbating the inflammatory response associated with spinal tuberculosis.Journal of orthopaedic surgery and research · 2025Article
- Review
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- Exploring TSPAN4 promoter methylation as a diagnostic biomarker for tuberculosis.Frontiers in genetics · 2024Article
- Epigenetic landscape of intestinal cell line HT29 cocultured withEpigenomics · 2024Article
- Pulmonary Pathogen-Induced Epigenetic Modifications.Epigenomes · 2023Review
- The spectrum of tuberculosis described as differential DNA methylation patterns in alveolar macrophages and alveolar T cells.Clinical epigenetics · 2022Article
- Review
- Epigenetic-Mediated Antimicrobial Resistance: Host versus Pathogen Epigenetic Alterations.Antibiotics (Basel, Switzerland) · 2022Review
- RNA Expression Analysis of Mycobacterial Methyltransferases Genes in Different Resistant Strains of Mycobacterium tuberculosis.Iranian biomedical journal · 2022Article
- In-depth systems biological evaluation of bovine alveolar macrophages suggests novel insights into molecular mechanisms underlyingFrontiers in microbiology · 2022Article
- MIAOME: Human microbiome affect the host epigenome.Computational and structural biotechnology journal · 2022Article
- A differential DNA methylome signature of pulmonary immune cells from individuals converting to latent tuberculosis infection.Scientific reports · 2021Article
- Strategies for advanced personalized tuberculosis diagnosis: Current technologies and clinical approaches.Precision clinical medicine · 2021Review
- Epigenetic interaction of microbes with their mammalian hosts.Journal of biosciences · 2021Article
- The Role of Host Cell DNA Methylation in the Immune Response to Bacterial Infection.Frontiers in immunology · 2021Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A mammalian cell utilizes DNA methylation to modulate gene expression in response to environmental changes during development and differentiation. Aberrant DNA methylation changes as a correlate to diseased states like cancer, neurodegenerative conditions and cardiovascular diseases have been documented. Here we show genome-wide DNA methylation changes in macrophages infected with the pathogen M. tuberculosis. Majority of the affected genomic loci were hypermethylated in M. tuberculosis infected THP1 macrophages. Hotspots of differential DNA methylation were enriched in genes involved in immune response and chromatin reorganization. Importantly, DNA methylation changes were observed predominantly for cytosines present in non-CpG dinucleotide context. This observation was consistent with our previous finding that the mycobacterial DNA methyltransferase, Rv2966c, targets non-CpG dinucleotides in the host DNA during M. tuberculosis infection and reiterates the hypothesis that pathogenic bacteria use non-canonical epigenetic strategies during infection.
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