ArticleBMC psychiatry2016
Quantifying the impact of chronic conditions on a diagnosis of major depressive disorder in adults: a cohort study using linked electronic medical records.
Article in BMC psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Relationship between social determinants of health and hospitalizations and costs in patients with major depressive disorder.Journal of managed care & specialty pharmacy · 2024Observational
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- Burden of Chronic Conditions Among Persons with HIV/AIDS and Psychiatric Comorbidity.Current HIV research · 2021Article
- Subphenotyping depression using machine learning and electronic health records.Learning health systems · 2020Article
- The Link Between Autonomic Nervous System and Rheumatoid Arthritis: From Bench to Bedside.Frontiers in medicine · 2020Review
- Depression in middle and older adulthood: the role of immigration, nutrition, and other determinants of health in the Canadian longitudinal study on aging.BMC psychiatry · 2019Article
- Associations between prevalent multimorbidity combinations and prospective disability and self-rated health among older adults in Europe.BMC geriatrics · 2019Article
- Effects of Pain, Insomnia, and Depression on Psychoactive Medication Supply in Older Adults With Osteoarthritis.Medical care · 2018Article
- Risk of Depression and Suicidality among Diabetic Patients: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2018Review
- Association networks in a matched case-control design - Co-occurrence patterns of preexisting chronic medical conditions in patients with major depression versus their matched controls.Journal of biomedical informatics · 2018Article
- Mental and Addictive Disorders and Medical Comorbidities.Current psychiatry reports · 2018Review
- The relation between obesity and depressed mood in a multi-ethnic population. The HELIUS study.Social psychiatry and psychiatric epidemiology · 2018Article
- Depression risk in patients with late-onset rheumatoid arthritis in Germany.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2017Article
- On Interestingness Measures for Mining Statistically Significant and Novel Clinical Associations from EMRs.ACM-BCB ... ... : the ... ACM Conference on Bioinformatics, Computational Biology and Biomedicine. ACM Conference on Bioinformatics, Computational Biology and Biomedicine · 2016Article
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundMajor depressive disorder (MDD) is often comorbid with other chronic mental and physical health conditions. Although the literature widely acknowledges the association of many chronic conditions with the risk of MDD, the relative importance of these conditions on MDD risk in the presence of other conditions is not well investigated. In this study, we aimed to quantify the relative contribution of selected chronic conditions to identify the conditions most influential to MDD risk in adults and identify differences by age.
methodsThis study used electronic health record (EHR) data on patients empanelled with primary care at Mayo Clinic in June 2013. A validated EHR-based algorithm was applied to identify newly diagnosed MDD patients between 2000 and 2013. Non-MDD controls were matched 1:1 to MDD cases on birth year (±2 years), sex, and outpatient clinic visits in the same year of MDD case diagnosis. Twenty-four chronic conditions defined by Chronic Conditions Data Warehouse were ascertained in both cases and controls using diagnosis codes within 5 years of index dates (diagnosis dates for cases, and the first clinic visit dates for matched controls). For each age group (45 years or younger, between 46 and 60, and over 60 years), conditional logistic regression models were used to test the association between each condition and subsequent MDD risk, adjusting for educational attainment and obesity. The relative influence of these conditions on the risk of MDD was quantified using gradient boosting machine models.
resultsA total of 11,375 incident MDD cases were identified between 2000 and 2013. Most chronic conditions (except for eye conditions) were associated with risk of MDD, with different association patterns observed depending on age. Among 24 chronic conditions, the greatest relative contribution was observed for diabetes mellitus for subjects aged ≤ 60 years and rheumatoid arthritis/osteoarthritis for those over 60 years.
conclusionsOur results suggest that specific chronic conditions such as diabetes mellitus and rheumatoid arthritis/osteoarthritis may have greater influence than others on the risk of MDD.
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