ArticleNeuron2016
Oxytocin Enhances Social Recognition by Modulating Cortical Control of Early Olfactory Processing.
Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 184 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
184 citing papers in PubMed, 361 citations in OpenAlex.
- Effects of single- and multiple-dose oxytocin treatment on amygdala low-frequency BOLD fluctuations and BOLD spectral dynamics in autism.Translational psychiatry · 2022Trial
- Oxytocin enhances neural approach towards social and non-social stimuli of high personal relevance.Scientific reports · 2021Trial
- Oxytocin increases eye gaze in schizophrenia.Schizophrenia research · 2019Trial
- Oxytocin increases eye-gaze towards novel social and non-social stimuli.Social neuroscience · 2019Trial
- Target-dependent routing of sensory information in the olfactory system.Communications biology · 2026Article
- Loss of oxytocin receptor function disrupts neural signatures of pair bonding and fidelity in the nucleus accumbens.Nature communications · 2026Article
- Article
- Sexually dimorphic organization of extracellular matrix and perineuronal nets in the prairie vole (Microtus ochrogaster) social brain.Brain structure & function · 2026Article
- Stable clique membership in male mouse societies requires oxytocin-enabled social sensory states.Nature communications · 2026Article
- Hippocampal communication with the anterior olfactory nucleus is necessary for context-dependent odor memory.Behavioral neuroscience · 2026Article
- Social and neuroendocrine phenotypes reprogrammed by endocrine-disrupting chemicals can be mitigated bybioRxiv : the preprint server for biology · 2026Article
- Beyond lactation: Central oxytocin in maternal mental health and disease.Neuroscience and biobehavioral reviews · 2026Review
- Oxytocin selectively biases sensory-prefrontal communication through network-level suppression and theta coupling.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Sex-specific regulation of social play in juvenile rats by oxytocin neurons in the hypothalamus and oxytocin signaling in the nucleus accumbens.Hormones and behavior · 2026Article
- An olfactory-prefrontal cortical circuit supports social recognition.Research square · 2026Article
- Article
- Oxytocin facilitates social behavior of female rats via selective modulation of interneurons in the medial prefrontal cortex.Nature communications · 2026Article
- SNAP-47 mediates somatic oxytocin dynamics in hypothalamic neurons.Communications biology · 2026Article
- Social exclusion selectively attenuates social reward processing but promotes prosocial evaluations.Social cognitive and affective neuroscience · 2026Article
- Oxytocin modulation of the insular cortex: implications for social cognition and neurodevelopmental disorders.Frontiers in neural circuits · 2026Review
124 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 5 institutions in 3 countries.
Funding
Abstract
Oxytocin promotes social interactions and recognition of conspecifics that rely on olfaction in most species. The circuit mechanisms through which oxytocin modifies olfactory processing are incompletely understood. Here, we observed that optogenetically induced oxytocin release enhanced olfactory exploration and same-sex recognition of adult rats. Consistent with oxytocin's function in the anterior olfactory cortex, particularly in social cue processing, region-selective receptor deletion impaired social recognition but left odor discrimination and recognition intact outside a social context. Oxytocin transiently increased the drive of the anterior olfactory cortex projecting to olfactory bulb interneurons. Cortical top-down recruitment of interneurons dynamically enhanced the inhibitory input to olfactory bulb projection neurons and increased the signal-to-noise of their output. In summary, oxytocin generates states for optimized information extraction in an early cortical top-down network that is required for social interactions with potential implications for sensory processing deficits in autism spectrum disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.