ArticleScientific reports2016
Hypomethylation of ERVs in the sperm of mice haploinsufficient for the histone methyltransferase Setdb1 correlates with a paternal effect on phenotype.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Transcriptome profiling of histone writers/erasers enzymes across spermatogenesis, mature sperm and pre-cleavage embryo: Implications in paternal epigenome transitions and inheritance mechanisms.Frontiers in cell and developmental biology · 2023Article
- Molecular mechanisms of transgenerational epigenetic inheritance.Nature reviews. Genetics · 2022Review
- Article
- EHMT2 suppresses the variation of transcriptional switches in the mouse embryo.PLoS genetics · 2021Article
- Article
- Human sperm displays rapid responses to diet.PLoS biology · 2019Article
- Sperm RNA code programmes the metabolic health of offspring.Nature reviews. Endocrinology · 2019Review
- The expanding repertoire of hereditary information carriers.Development (Cambridge, England) · 2019Article
- Reduced PRC2 function alters male germline epigenetic programming and paternal inheritance.BMC biology · 2018Article
- Epigenetic control of variation and stochasticity in metabolic disease.Molecular metabolism · 2018Review
- Out of sight, out of mind? Germ cells and the potential impacts of epigenomic drugs.F1000Research · 2018Review
- Tissue-specific DNA methylation is conserved across human, mouse, and rat, and driven by primary sequence conservation.BMC genomics · 2017Article
- Epigenetic Mechanisms of Transmission of Metabolic Disease across Generations.Cell metabolism · 2017Review
- Developmental origins of male subfertility: role of infection, inflammation, and environmental factors.Seminars in immunopathology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The number of reports of paternal epigenetic influences on the phenotype of offspring in rodents is increasing but the molecular events involved remain unclear. Here, we show that haploinsufficiency for the histone 3 lysine 9 methyltransferase Setdb1 in the sire can influence the coat colour phenotype of wild type offspring. This effect occurs when the allele that directly drives coat colour is inherited from the dam, inferring that the effect involves an "in trans" step. The implication of this finding is that epigenetic state of the sperm can alter the expression of genes inherited on the maternally derived chromosomes. Whole genome bisulphite sequencing revealed that Setdb1 mutant mice show DNA hypomethylation at specific classes of transposable elements in the sperm. Our results identify Setdb1 as a paternal effect gene in the mouse and suggest that epigenetic inheritance may be more likely in individuals with altered levels of epigenetic modifiers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.