Evidence map›Paper›PMID 27112429›Full record

ReviewThe New phytologist2016

Plant metabolic clusters - from genetics to genomics.

Hans-Wilhelm Nützmann, Ancheng Huang, Anne Osbourn

Abstract readReview
In one paragraph

Review in The New phytologist, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 164 papers.

0numbers the graph read from it
0cells of the map it votes in
164citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

164 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
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  9. Article
  10. Article
  11. Article
  12. Article
  13. Chromosome-level genome assembly ofHorticulture research · 2026
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Synteny Analysis and Visualization of Gene Clusters.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  19. Mining Metabolic Diversities Across Genomic Neighborhoods in Plants.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  20. Article

104 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hans-Wilhelm NützmannDepartment of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK.
Ancheng HuangDepartment of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK.
Anne OsbournDepartment of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK.

Funding

An integrated pipeline for accelerated plant natural product discoveryU01GM110699 · NIGMS · STANFORD UNIVERSITY · PI SMOLKE, CHRISTINA D · 2015 to 2019
$4.5M
Biotechnology and Biological Sciences Research Council BB/J004561/1Biotechnology and Biological Sciences Research Council BB/L014130/1Biotechnology and Biological Sciences Research Council BB/M028860/1Biotechnology and Biological Sciences Research Council BBS/E/J/00000614NIGMS NIH HHS U01 GM110699
6 · The paper itself

Abstract

Contents 771 I. 771 II. 772 III. 780 IV. 781 V. 786 786 References 786 SUMMARY: Plant natural products are of great value for agriculture, medicine and a wide range of other industrial applications. The discovery of new plant natural product pathways is currently being revolutionized by two key developments. First, breakthroughs in sequencing technology and reduced cost of sequencing are accelerating the ability to find enzymes and pathways for the biosynthesis of new natural products by identifying the underlying genes. Second, there are now multiple examples in which the genes encoding certain natural product pathways have been found to be grouped together in biosynthetic gene clusters within plant genomes. These advances are now making it possible to develop strategies for systematically mining multiple plant genomes for the discovery of new enzymes, pathways and chemistries. Increased knowledge of the features of plant metabolic gene clusters - architecture, regulation and assembly - will be instrumental in expediting natural product discovery. This review summarizes progress in this area.

Indexed as

GenomicsBiological ProductsBiosynthetic PathwaysMultigene FamilyPlantsBiological Productsbiosynthetic gene clusterschromatingenome miningnatural productsoperons

Identifiers

PMID27112429
PMCPMC5449196

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.