ArticleScientific reports2016
Assessment of Fat distribution and Bone quality with Trabecular Bone Score (TBS) in Healthy Chinese Men.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 67 citations in OpenAlex.
- Effect of metformin and insulin vs. placebo and insulin on whole body composition in overweight patients with type 2 diabetes: a randomized placebo-controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Trial
- Changes in spinal bone density, back muscle size, and visceral adipose tissue and their interaction following a multi-component exercise program in older men: secondary analysis of an 18-month randomized controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Trial
- Associations of long-term waist circumference trajectories with the risk of fragility fractures: a prospective cohort study.Journal of endocrinological investigation · 2026Article
- Association Between Arterial Stiffness and Bone Microarchitectural Deterioration in Type 2 Diabetes: A Cross-Sectional Study.Journal of diabetes · 2025Article
- Association between A body shape index and bone mineral density in middle-aged and elderly adults: a retrospective analysis of NHANES 2005-2018.Frontiers in endocrinology · 2025Article
- Obesity and Skeletal Fragility.The Journal of clinical endocrinology and metabolism · 2024Review
- Areal bone mineral density, trabecular bone score and 3D-DXA analysis of proximal femur in psoriatic disease.Frontiers in medicine · 2024Article
- The association between body roundness index and osteoporosis in American adults: analysis from NHANES dataset.Frontiers in nutrition · 2024Article
- Added value of waist circumference to body mass index for predicting fracture risk in obesity: a prospective study from the CARTaGENE cohort.Archives of osteoporosis · 2023Article
- Gender-specific impacts of thigh skinfold thickness and grip strength for predicting osteoporosis in type 2 diabetes.Diabetology & metabolic syndrome · 2023Article
- The effect of body size and composition on lumbar spine trabecular bone score in morphologically diverse subjects.PloS one · 2023Article
- Age, body composition parameters and glycaemic control contribute to trabecular bone score deterioration in acromegaly more than disease activity.Frontiers in endocrinology · 2023Article
- Factors associated with trabecular bone score in postmenopausal women with type 2 diabetes and normal bone mineral density.World journal of diabetes · 2022Article
- The association between body fat distribution and bone mineral density: evidence from the US population.BMC endocrine disorders · 2022Article
- Body Composition as a Modulator of Bone Health Changes in Patients with Inflammatory Bowel Disease.Life (Basel, Switzerland) · 2022Article
- Factors associated with TBS worse than BMD in non-osteoporotic elderly population: Bushehr elderly health program.BMC geriatrics · 2021Article
- Effects of metabolic syndrome on bone health in older adults: the Bushehr Elderly Health (BEH) program.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- Reduction of visceral fat could be related to the improvement of TBS in diabetes mellitus.Journal of bone and mineral metabolism · 2020Article
- Relationship of Two-Hour Plasma Glucose and Abdominal Visceral Fat with Bone Mineral Density and Bone Mineral Content in Women with Different Glucose Metabolism Status.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Trabecular Bone Score in Obese and Nonobese Subjects With Primary Hyperparathyroidism Before and After Parathyroidectomy.The Journal of clinical endocrinology and metabolism · 2018Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whether fat is beneficial or detrimental to bones is still controversial, which may be due to inequivalence of the fat mass. Our objective is to define the effect of body fat and its distribution on bone quality in healthy Chinese men. A total of 228 men, aged from 38 to 89 years, were recruited. BMD, trabecular bone score (TBS), and body fat distribution were measured by dual-energy X-ray absorptiometry. Subcutaneous and visceral fat were assessed by MRI. In the Pearson correlation analysis, lumbar spine BMD exhibited positive associations with total and all regional fat depots, regardless of the fat distribution. However, the correlation disappeared with adjusted covariables of age, BMI, HDL-C, and HbA1c%. TBS was negatively correlated with fat mass. In multiple linear regression models, android fat (and not gynoid, trunk, or limbs fat) showed significant inverse association with TBS (β = -0.611, P < 0.001). Furthermore, visceral fat was described as a pathogenic fat harmful to TBS, even after adjusting for age and BMI (β = -0.280, P = 0.017). Our findings suggested that body fat mass, especially android fat and visceral fat, may have negative effects on bone microstructure; whereas body fat mass contributes to BMD through mechanical loading.
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