ArticleScientific reports2016
Odorant receptors of Drosophila are sensitive to the molecular volume of odorants.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
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- Operational mechanisms and application advances in artificial olfactory systems.Biomedical engineering online · 2026Review
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- Mosquito Olfactory Response Ensemble enables pattern discovery by curating a behavioral and electrophysiological response database.iScience · 2022Article
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- Functional conservation of Anopheline linalool receptors through 100 million years of evolution.Chemical senses · 2022Article
- Vibration-based biomimetic odor classification.Scientific reports · 2021Article
- Sensory Perception of Non-Deuterated and Deuterated Organic Compounds.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Copper-mediated thiol potentiation and mutagenesis-guided modeling suggest a highly conserved copper-binding motif in human OR2M3.Cellular and molecular life sciences : CMLS · 2020Article
- Identification and Expression Profiling of Peripheral Olfactory Genes in the Parasitoid WaspInsects · 2019Article
- Sequence-Based Prediction of Olfactory Receptor Responses.Chemical senses · 2019Article
- Shining Light on Molecular Mechanism for Odor-selectivity of CNT-immobilized Olfactory Receptor.Scientific reports · 2018Article
- A Quantum Biomimetic Electronic Nose Sensor.Scientific reports · 2018Article
- Applications and Advances in Bioelectronic Noses for Odour Sensing.Sensors (Basel, Switzerland) · 2018Review
- The Role of Diet in Shaping the Chemical Signal Design of Lacertid Lizards.Journal of chemical ecology · 2017Article
- Experimental evaluation of the generalized vibrational theory of G protein-coupled receptor activation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- DoOR 2.0--Comprehensive Mapping of Drosophila melanogaster Odorant Responses.Scientific reports · 2016Article
- Adaptive Membrane Fluidity Modulation: A Feedback Regulated Homeostatic System and Target for Pharmacological Intervention.In vivo (Athens, Greece)Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Which properties of a molecule define its odor? This is a basic yet unanswered question regarding the olfactory system. The olfactory system of Drosophila has a repertoire of approximately 60 odorant receptors. Molecules bind to odorant receptors with different affinities and activate them with different efficacies, thus providing a combinatorial code that identifies odorants. We hypothesized that the binding affinity of an odorant-receptor pair is affected by their relative sizes. The maximum affinity can be attained when the molecular volume of an odorant matches the volume of the binding pocket. The affinity drops to zero when the sizes are too different, thus obscuring the effects of other molecular properties. We developed a mathematical formulation of this hypothesis and verified it using Drosophila data. We also predicted the volume and structural flexibility of the binding site of each odorant receptor; these features significantly differ between odorant receptors. The differences in the volumes and structural flexibilities of different odorant receptor binding sites may explain the difference in the scents of similar molecules with different sizes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.