ArticleStress (Amsterdam, Netherlands)2016
Cumulative stress and autonomic dysregulation in a community sample.
Article in Stress (Amsterdam, Netherlands), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07288593 (Insomnia, Nightmares, and Sympathetic Hyperactivity Intervention in the warfiGHTer), which is not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Insomnia, Nightmares, and Sympathetic Hyperactivity Intervention in the warfiGHTer (INSIGHT)
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of stress management interventions on heart rate variability in adults with cardiovascular disease: a systematic review and meta-analysis.Journal of behavioral medicine · 2024Pooled it
- Day and night heart rate variability using 24-h ECG recordings: a systematic review with meta-analysis using a gender lens.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Pooled it
- Early alcohol abstinence symptoms and the role of cumulative adversity.Alcohol, clinical & experimental research · 2025Article
- Longitudinal effects of stress in an academic context on psychological well-being, physiological markers, health behaviors, and academic performance in university students.BMC psychology · 2025Article
- Long-term alteration of heart rate variability following childhood maltreatment: Results of a general population study.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- The Impacts of Housing Conditions on the Cardiopulmonary and Neurobehavioral Responses of Mice to High Temperature and Wildfire Smoke.Environmental science & technology · 2025Article
- Immigration stress and maternal sensitivity in a Mexican immigrant sample: The role of parasympathetic activity and familism value.Cultural diversity & ethnic minority psychology · 2024Article
- A novel approach to model cumulative stress: Area under the s-factor curve.Social science & medicine (1982) · 2024Article
- The Influence of Social Dynamics on Biological Aging and the Health of Historically Marginalized Populations: A Biopsychosocial Model for Health Disparities.International journal of environmental research and public health · 2024Review
- Perceived Parenting Stress Is Related to Cardiac Flexibility in Mothers: Data from the NorBaby Study.Behavioral sciences (Basel, Switzerland) · 2024Article
- Parent Stress and Trauma, Autonomic Responses, and Negative Child Behaviors.Child psychiatry and human development · 2023Article
- Examining the effects of cumulative environmental stressors on Gulf Coast child and adolescent health.Population and environment · 2023Article
- Regular cannabis use is associated with history of childhood and lifetime trauma in a non-clinical community sample.Journal of psychiatric research · 2023Article
- Resting-state heart rate variability (HRV) mediates the association between perceived chronic stress and ambiguity avoidance.Scientific reports · 2022Article
- Decreased self-reported receiving of social touch and social support predict loneliness in healthy adults.Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS · 2022Article
- Hypertension and Diabetes Status by Patterns of Stress in Older Adults From the US Health and Retirement Study: A Latent Class Analysis.Journal of the American Heart Association · 2022Article
- Early childhood lead exposure and adolescent heart rate variability: A longitudinal cohort study.Environmental research · 2022Article
- Pure purr virtual reality technology: measuring heart rate variability and anxiety levels in healthy volunteers affected by moderate stress.Archives of medical science : AMS · 2022Article
- The cumulative effect of chronic stress and depressive symptoms affects heart rate in a working population.Frontiers in psychiatry · 2022Article
- The Moderating Role of Coping Style on Chronic Stress Exposure and Cardiovascular Reactivity Among African American Emerging Adults.Prevention science : the official journal of the Society for Prevention Research · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Whether cumulative stress, including both chronic stress and adverse life events, is associated with decreased heart rate variability (HRV), a non-invasive measure of autonomic status which predicts poor cardiovascular outcomes, is unknown. Healthy community dwelling volunteers (N = 157, mean age 29 years) participated in the Cumulative Stress/Adversity Interview (CAI), a 140-item event interview measuring cumulative adversity including major life events, life trauma, recent life events and chronic stressors, and underwent 24-h ambulatory ECG monitoring. HRV was analyzed in the frequency domain and standard deviation of NN intervals (SDNN) calculated. Initial simple regression analyses revealed that total cumulative stress score, chronic stressors and cumulative adverse life events (CALE) were all inversely associated with ultra low-frequency (ULF), very low-frequency (VLF) and low-frequency (LF) power and SDNN (all p < 0.05). In hierarchical regression analyses, total cumulative stress and chronic stress each was significantly associated with SDNN and ULF even after the highly significant contributions of age and sex, with no other covariates accounting for additional appreciable variance. For VLF and LF, both total cumulative stress and chronic stress significantly contributed to the variance alone but were not longer significant after adjusting for race and health behaviors. In summary, total cumulative stress, and its components of adverse life events and chronic stress were associated with decreased cardiac autonomic function as measured by HRV. Findings suggest one potential mechanism by which stress may exert adverse effects on mortality in healthy individuals. Primary preventive strategies including stress management may prove beneficial.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.