Trial reportThe Journal of pediatrics2016
Impact of Tight Glycemic Control on Neurodevelopmental Outcomes at 1 Year of Age for Children with Congenital Heart Disease: A Randomized Controlled Trial.
Trial report in The Journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00443599 (Maintaining Normal Blood Sugar Levels in Children Undergoing Heart Surgery to Reduce the Risk of Infections and Improve Recovery), which is not on this map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Maintaining Normal Blood Sugar Levels in Children Undergoing Heart Surgery to Reduce the Risk of Infections and Improve Recovery (The SPECS Study)
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Early Emotional, Behavioural and Social Development of Infants and Young Children with Congenital Heart Disease: A Systematic Review.Journal of clinical psychology in medical settings · 2020Pooled it
- Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children.Intensive care medicine · 2020Guideline
- Tight glycemic control in critically ill pediatric patients: a meta-analysis and systematic review of randomized controlled trials.Pediatric research · 2018Pooled it
- Tight glycemic control in critically ill pediatric patients: a meta-analysis and systematic review of randomized controlled trials.Pediatric research · 2018Pooled it
- Methylprednisolone for Infant Heart Surgery: Subpopulation Analyses of a Randomized Controlled Trial.Critical care medicine · 2025Trial
- Impact of tight glycemic control and hypoglycemia after pediatric cardiac surgery on neurodevelopmental outcomes at three years of age: Findings from a randomized clinical trial.BMC pediatrics · 2022Trial
- Long-Term Neurobehavioral and Quality of Life Outcomes of Critically Ill Children after Glycemic Control.The Journal of pediatrics · 2020Trial
- Design and rationale of Heart and Lung Failure - Pediatric INsulin Titration Trial (HALF-PINT): A randomized clinical trial of tight glycemic control in hyperglycemic critically ill children.Contemporary clinical trials · 2017Trial
- Research gaps in the neurodevelopmental assessment of children with complex congenital heart defects: a scoping review.Frontiers in pediatrics · 2024Article
- The association of hypoglycemia with outcome of critically ill children in relation to nutritional and blood glucose control strategies.Critical care (London, England) · 2023Article
- The Current Status of Neuroprotection in Congenital Heart Disease.Children (Basel, Switzerland) · 2021Review
- Neonatal hyperglycaemia is associated with worse neurodevelopmental outcomes in extremely preterm infants.Archives of disease in childhood. Fetal and neonatal edition · 2021Observational
- Critical Care Management of Stress-Induced Hyperglycemia.Current diabetes reports · 2018Review
- Nutrition Support and Tight Glucose Control in Critically Ill Children: Food for Thought!Frontiers in pediatrics · 2018Article
- The Metabolic Response to Stress and Infection in Critically Ill Children: The Opportunity of an Individualized Approach.Nutrients · 2017Review
- The intensive care medicine clinical research agenda in paediatrics.Intensive care medicine · 2017Review
- Neurodevelopmental Abnormalities and Congenital Heart Disease: Insights Into Altered Brain Maturation.Circulation research · 2017Review
- Pediatric Multiple Organ Dysfunction Syndrome: Promising Therapies.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2017Review
- Optimizing nutrition of the preterm infant.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Article
- Is intraoperative supplementation of dextrose essential for infants undergoing facial cleft surgeries?Journal of anaesthesiology, clinical pharmacologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
objectiveTo assess the association of postoperative tight glycemic control and hypoglycemia in children undergoing cardiac surgery with neurodevelopmental outcomes at 1 year of age. STUDY
designA 2-center, prospective, randomized trial of postoperative tight glycemic control vs standard care was conducted in 980 children undergoing cardiac surgery. Neurodevelopmental outcomes were assessed at nine to 18 months using the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III), the Adaptive Behavior Assessment System, Second Edition, the Ages and Stages Questionnaire, Third Edition, and the Brief Infant Toddler Social-Emotional Assessment.
resultsNeurodevelopmental follow-up was performed on 237 patients with a mean age of 13 months. No significant treatment group differences were found in the Bayley-III and Adaptive Behavior Assessment System, Second Edition composite scores or percentage at risk based on the Ages and Stages Questionnaire, Third Edition and the Brief Infant Toddler Social-Emotional Assessment. Patients who experienced moderate to severe hypoglycemia (n = 8) had lower Bayley-III composite scores compared with patients with no to mild hypoglycemia, even after controlling for factors known to be associated with poorer neurodevelopmental outcomes.
conclusionFor infants undergoing cardiac surgery, tight glycemic control did not impact neurodevelopmental outcomes compared with standard care. These data suggest a possible association between moderate to severe hypoglycemia and poorer neurodevelopmental outcomes at 1 year of age.
trial registrationClinicalTrials.gov: NCT00443599.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.