Evidence map›Paper›PMID 27111757›Full record

ArticleAdvanced healthcare materials2016

Developing Precisely Defined Drug-Loaded Nanoparticles by Ring-Opening Polymerization of a Paclitaxel Prodrug.

Jinyao Liu, Yan Pang, Jayanta Bhattacharyya, Wenge Liu, Isaac Weitzhandler, Xinghai Li, Ashutosh Chilkoti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jinyao LiuDepartment of Biomedical Engineering, Center for Biologically Inspired Materials and Material Systems, Duke University, Durham, NC, 27708, USA.
Yan PangDepartment of Biomedical Engineering, Center for Biologically Inspired Materials and Material Systems, Duke University, Durham, NC, 27708, USA.
Jayanta BhattacharyyaDepartment of Biomedical Engineering, Center for Biologically Inspired Materials and Material Systems, Duke University, Durham, NC, 27708, USA.
Wenge LiuDepartment of Biomedical Engineering, Center for Biologically Inspired Materials and Material Systems, Duke University, Durham, NC, 27708, USA.
Isaac WeitzhandlerDepartment of Biomedical Engineering, Center for Biologically Inspired Materials and Material Systems, Duke University, Durham, NC, 27708, USA.
Xinghai LiDepartment of Biomedical Engineering, Center for Biologically Inspired Materials and Material Systems, Duke University, Durham, NC, 27708, USA.
Ashutosh ChilkotiDepartment of Biomedical Engineering, Center for Biologically Inspired Materials and Material Systems, Duke University, Durham, NC, 27708, USA.

Funding

Thermally Targeted Drug Delivery by Elastin BiopolymersR01EB000188 · NIBIB · DUKE UNIVERSITY · PI CHILKOTI, ASHUTOSH · 2002 to 2015
$3.9M
Thermally Triggered Multivalent Targeting of TumorsR01EB007205 · NIBIB · DUKE UNIVERSITY · PI CHILKOTI, ASHUTOSH · 2007 to 2015
$2.7M
NIBIB NIH HHS R01 EB000188NIBIB NIH HHS R01 EB007205
6 · The paper itself

Abstract

Nanoparticles with high paclitaxel (PTX) loading and low systemic toxicity are prepared in scalable and versatile manner via one-step ring-opening polymerization of a prodrug monomer consisting of PTX that is appended to a cyclic carbonate through a hydrolysable ester linker. Initiating this monomer from a hydrophilic macroinitiator results in an amphiphilic diblock copolymer that spontaneously self-assembles into well-defined nanoparticles with tunable size.

Indexed as

Drug CarriersCell Line, TumorFemaleHumansNanoparticlesPaclitaxelParticle SizeProdrugsDrug CarriersPaclitaxelProdrugsanticancernanoparticlepaclitaxelprodrugring-opening polymerization

Identifiers

PMID27111757
PMCPMC5279999

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.