Observational studyArthritis & rheumatology (Hoboken, N.J.)2016
Nailfold Videocapillaroscopic Features and Other Clinical Risk Factors for Digital Ulcers in Systemic Sclerosis: A Multicenter, Prospective Cohort Study.
Observational study in Arthritis & rheumatology (Hoboken, N.J.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 152 citations in OpenAlex.
- Nailfold capillaroscopy in patients with systemic sclerosis-associated interstitial lung disease: a substudy of the SENSCIS trial.RMD open · 2025Trial
- Ultrasound characterization of cutaneous ulcers in systemic sclerosis.Clinical rheumatology · 2018Trial
- Review
- Microvascular markers in systemic sclerosis: a comparative OCT-angiography and nailfold videocapillaroscopy study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Article
- Nailfold video capillaroscopy in patients with suspected systemic sclerosis: a comparison of one-finger method versus eight-finger method.Journal of scleroderma and related disorders · 2026Article
- Precision-targeted nanodelivery systems for intra-articular treatment of knee osteoarthritis: recent breakthroughs and translational challenges.Frontiers in bioengineering and biotechnology · 2026Review
- Systemic sclerosis: pathogenic mechanisms and their implications for treatment.Seminars in immunopathology · 2025Review
- Systemic sclerosis in Egyptian population with emphasis on clinical and nailfold capillaroscopic features.Scientific reports · 2025Article
- Prevalence and clinical relevance of digital ulcers in systemic sclerosis patients from the real-life: the experience of the SPRING Registry of the Italian Society for Rheumatology.Clinical rheumatology · 2025Article
- Review
- The predictive value of anti-IFI16 antibodies for the development or persistence of digital ulcers in systemic sclerosis.Clinical rheumatology · 2025Article
- Prevalence, causes, and clinical associations of anemia in patients with systemic sclerosis: A cohort study.Journal of scleroderma and related disorders · 2024Article
- Automated Laser-Fiber Coupling Module for Optical-Resolution Photoacoustic Microscopy.Sensors (Basel, Switzerland) · 2023Article
- Vision transformer assisting rheumatologists in screening for capillaroscopy changes in systemic sclerosis: an artificial intelligence model.Rheumatology (Oxford, England) · 2023Article
- Correlations between capillary density and degree of skin pigmentation in healthy children analysed by nailfold video capillaroscopy.Quantitative imaging in medicine and surgery · 2023Article
- Article
- Correlation between Microvascular Damage and Internal Organ Involvement in Scleroderma: Focus on Lung Damage and Endothelial Dysfunction.Diagnostics (Basel, Switzerland) · 2022Review
- Nailfold capillaroscopy: tips and challenges.Clinical rheumatology · 2022Review
- Photoacoustic imaging is a novel tool to measure finger artery structure and oxygenation in patients with SSc.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
16 authors at 12 institutions in 9 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo identify nailfold videocapillaroscopic features and other clinical risk factors for new digital ulcers (DUs) during a 6-month period in patients with systemic sclerosis (SSc).
methodsIn this multicenter, prospective, observational cohort study, the videoCAPillaroscopy (CAP) study, we evaluated 623 patients with SSc from 59 centers (14 countries). Patients were stratified into 2 groups: a DU history group and a no DU history group. At enrollment, patients underwent detailed nailfold videocapillaroscopic evaluation and assessment of demographic characteristics, DU status, and clinical and SSc characteristics. Risk factors for developing new DUs were assessed using univariable and multivariable logistic regression (MLR) analyses.
resultsOf the 468 patients in the DU history group (mean ± SD age 54.0 ± 13.7 years), 79.5% were female, 59.8% had limited cutaneous SSc, and 22% developed a new DU during follow-up. The strongest risk factors for new DUs identified by MLR in the DU history group included the mean number of capillaries per millimeter in the middle finger of the dominant hand, the number of DUs (categorized as 0, 1, 2, or ≥3), and the presence of critical digital ischemia. The receiver operating characteristic (ROC) of the area under the curve (AUC) of the final MLR model was 0.738 (95% confidence interval [95% CI] 0.681-0.795). Internal validation through bootstrap generated a ROC AUC of 0.633 (95% CI 0.510-0.756).
conclusionThis international prospective study, which included detailed nailfold videocapillaroscopic evaluation and extensive clinical characterization of patients with SSc, identified the mean number of capillaries per millimeter in the middle finger of the dominant hand, the number of DUs at enrollment, and the presence of critical digital ischemia at enrollment as risk factors for the development of new DUs.
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