ArticlePsychology and aging2016
Older age may offset genetic influence on affect: The COMT polymorphism and affective well-being across the life span.
Article in Psychology and aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- A Re-evaluation of Candidate Gene Studies for Well-Being in Light of Genome-Wide Evidence.Journal of happiness studies · 2022Article
- No Evidence That Schizophrenia Candidate Genes Are More Associated With Schizophrenia Than Noncandidate Genes.Biological psychiatry · 2017Article
- Moment-to-moment within-person associations between acts of discrimination and internalized stigma in people living with HIV: An experience sampling study.Stigma and health · 2017Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The catechol-O-methyltransferase (COMT_Val158Met) genetic polymorphism has been linked to variation in affective well-being. Compared with Val carriers, Met carriers experience lower affective well-being. In parallel, research on aging and affective experience finds that younger adults experience poorer affective well-being than older adults. This study examined how COMT and age may interact to shape daily affective experience across the life span. Results suggest that Met (vs. Val) carriers experience lower levels of affective well-being in younger but not in older ages. These findings suggest that age-related improvements in emotional functioning may offset genetic vulnerabilities to negative affective experience. (PsycINFO Database Record
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.