ArticleNeuropsychology2016
Temporal course of neurodegenerative effects on cognition in old age.
Article in Neuropsychology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
28 citing papers in PubMed, 39 citations in OpenAlex.
- Associations of Alzheimer Disease and Related Dementia Neuropathologies With Timely Diagnosis of Dementia in Healthcare Settings.Neurology · 2026Article
- Mixed Pathologies and Cognitive Outcomes in Persons Considered for Anti-Amyloid Treatment Eligibility Assessment: A Community-Based Study.Neurology · 2025Article
- Cognitive performance and mortality among patients receiving autologous hematopoietic stem cell transplant.Journal of psychosocial oncology · 2024Article
- nlive: an R package to facilitate the application of the sigmoidal and random changepoint mixed models.BMC medical research methodology · 2023Article
- Costs During the Last Five Years of Life for Patients with Clinical and Pathological Confirmed Diagnosis of Lewy Body Dementia and Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2023Article
- Cognitive decline and alcohol consumption in the aging population-A longitudinal analysis of the Survey of Health, Ageing and Retirement in Europe.European psychiatry : the journal of the Association of European Psychiatrists · 2022Article
- Contribution of Alzheimer's biomarkers and risk factors to cognitive impairment and decline across the Alzheimer's disease continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Clinical Trajectories at the End of Life in Autopsy-Confirmed Dementia Patients With Alzheimer Disease and Lewy Bodies Pathologies.Neurology · 2022Article
- Glial TDP-43 and TDP-43 induced glial pathology, focus on neurodegenerative proteinopathy syndromes.Glia · 2022Review
- Mixed Neuropathologies, Neural Motor Resilience and Target Discovery for Therapies of Late-Life Motor Impairment.Frontiers in human neuroscience · 2022Article
- Person-Specific Contributions of Brain Pathologies to Progressive Parkinsonism in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Four Common Late-Life Cognitive Trajectories Patterns Associate with Replicable Underlying Neuropathologies.Journal of Alzheimer's disease : JAD · 2021Article
- Alzheimer's Disease Neuropathological Comorbidities are Common in the Younger-Old.Journal of Alzheimer's disease : JAD · 2021Article
- Stages of Objective Memory Impairment Predict Alzheimer's Disease Neuropathology: Comparison with the Clinical Dementia Rating Scale-Sum of Boxes.Journal of Alzheimer's disease : JAD · 2021Article
- TAR DNA-Binding Protein 43 Is Associated with Rate of Memory, Functional and Global Cognitive Decline in the Decade Prior to Death.Journal of Alzheimer's disease : JAD · 2021Article
- Limbic-predominant age-related TDP-43 encephalopathy, ADNC pathology, and cognitive decline in aging.Neurology · 2020Article
- Normative Cognitive Decline in Old Age.Annals of neurology · 2020Article
- Total Daily Physical Activity and the Risk of Parkinsonism in Community-Dwelling Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Proportion of cognitive loss attributable to terminal decline.Neurology · 2020Article
- Severe hyposmia distinguishes neuropathologically confirmed dementia with Lewy bodies from Alzheimer's disease dementia.PloS one · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo test the hypothesis that different forms of neurodegeneration are differentially related to longitudinal cognitive trajectories in old age.
methodsParticipants are 420 older persons from 2 clinical-pathologic studies without cognitive impairment at study onset. They completed a battery of 17 cognitive tests annually for a minimum of 5 years, died, and underwent a neuropathologic examination to quantify neuronal neurofibrillary tangles and transactive response DNA-binding protein 43 (TDP-43) pathology and to identify Lewy bodies and hippocampal sclerosis. The authors used sigmoid mixed models based on the 4-parameter logistic distribution to decompose nonlinear global cognitive trajectories into components and assess the relation of each neuropathologic marker to each trajectory component.
resultsCognitive function was assessed for a mean of 10.5 years before death. In the absence of pathology, global cognition was relatively stable before declining moderately in the last 3 to 4 years of life. Tangles were related to all trajectory components except initial level. TDP-43 pathology was the only marker related to initial level of function. It was also associated with an earlier midpoint of decline but not to slope of decline. Hippocampal sclerosis was related to an earlier midpoint of decline and more rapid slope of decline. Lewy bodies were associated with faster slope of decline and lower level of function proximate to death.
conclusionNeurodegenerative processes are differentially related to cognitive trajectories, with TDP-43 pathology most potently impacting incipient cognitive decline, AD pathology and hippocampal sclerosis affecting the progression of cognitive decline, and Lewy bodies impacting terminal decline. (PsycINFO Database Record
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.