ArticleNature medicine2016
Interictal epileptiform discharges induce hippocampal-cortical coupling in temporal lobe epilepsy.
Article in Nature medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 170 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
170 citing papers in PubMed, 2 syntheses or guidelines pooled it, 337 citations in OpenAlex.
- Does epileptic activity impair sleep-related memory consolidation in epilepsy? A critical and systematic review.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Pooled it
- Sleep and Temporal Lobe Epilepsy - Associations, Mechanisms and Treatment Implications.Frontiers in human neuroscience · 2022Pooled it
- Closed-loop modulation of sleep in children undergoing intracranial recordings.Cell reports. Medicine · 2026Trial
- Organic electronics for high-resolution electrocorticography of the human brain.Science advances · 2016Trial
- Trial
- Hippocampal ripples initiate cortical dimensionality expansion for memory retrieval.Nature communications · 2026Article
- Human hippocampal ripples coordinate planning sequences and compositional representations in neocortex.Nature neuroscience · 2026Article
- Hearing in Our Sleep-Can We Drown Out Epileptic Spikes and Boost Cognition?Epilepsy currents · 2026Article
- Epileptiform Discharges Drive Unique High-frequency Oscillations Within the Retrosplenial Cortex of Mice with Third Trimester Alcohol Exposure.bioRxiv : the preprint server for biology · 2026Article
- Hippocampal Long Axis Differentiation in Memory and Seizure Networks.Epilepsy currents · 2026Article
- Human neuronal firing varies with the frequency of local field potential oscillations.PLoS biology · 2026Article
- Flexible goal learning involves coordinated population activity in dCA1 and medial orbitofrontal cortex.PLoS biology · 2026Article
- Non-vectorial integration of intersectional short-pulse stimulation enables enhanced deep brain modulation and effective seizure control.Communications medicine · 2026Article
- Eye movements reflect memory-related theta activity in the human brain.PLoS biology · 2026Article
- Dysfunction of GABAergic interneurons underlies altered neural network oscillations associated with epileptiform activity in PPT1-deficient mice.Translational psychiatry · 2026Article
- Areas of research priorities in epilepsy: A position paper of the European Reference Network for Rare and Complex Epilepsies, EpiCARE.Epilepsia open · 2026Article
- Aperiodic 1/f noise drives ripple activity in humans.Nature communications · 2026Article
- Multistage sleep recordings: a missing piece in the puzzle of human interictal single-neuron dynamics.Brain communications · 2026Article
- Hippocampal interictal discharges induce frontal spindles and enhance spindle-slow oscillation coupling in temporal lobe epilepsy.Clinical neurophysiology practice · 2026Article
- Spatiotemporal patterns differentiate hippocampal sharp-wave ripples from interictal epileptiform discharges in mice and humans.Nature communications · 2025Article
110 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Interactions between the hippocampus and the cortex are critical for memory. Interictal epileptiform discharges (IEDs) identify epileptic brain regions and can impair memory, but the mechanisms by which they interact with physiological patterns of network activity are mostly undefined. We show in a rat model of temporal lobe epilepsy that spontaneous hippocampal IEDs correlate with impaired memory consolidation, and that they are precisely coordinated with spindle oscillations in the prefrontal cortex during nonrapid-eye-movement (NREM) sleep. This coordination surpasses the normal physiological ripple-spindle coupling and is accompanied by decreased ripple occurrence. IEDs also induce spindles during rapid-eye movement (REM) sleep and wakefulness-behavioral states that do not naturally express these oscillations-by generating a cortical 'down' state. In a pilot clinical examination of four subjects with focal epilepsy, we confirm a similar correlation of temporofrontal IEDs with spindles over anatomically restricted cortical regions. These findings imply that IEDs may impair memory via the misappropriation of physiological mechanisms for hippocampal-cortical coupling, which suggests a target for the treatment of memory impairment in epilepsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.