Evidence map›Paper›PMID 27110819›Full record

ReviewNutrients2016

Vitamin D and Autism Spectrum Disorder: A Literature Review.

Hajar Mazahery, Carlos A Camargo, Cathryn Conlon, Kathryn L Beck, Marlena C Kruger, Pamela R von Hurst

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 5 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 5 syntheses or guidelines pooled it, 110 citations in OpenAlex.

  1. Steroid hormone pathways, vitamin D and autism: a systematic review.Journal of neural transmission (Vienna, Austria : 1996) · 2023
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  8. Effects ofNutrients · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Hajar MazaheryInstitute of Food Science and Technology-School of Food and Nutrition, Massey University, Palmerston North 4474, New Zealand. h.mazahery@hotmail.com.
Carlos A CamargoDepartment of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. ccamargo@partners.org.
Cathryn ConlonInstitute of Food Science and Technology-School of Food and Nutrition, Massey University, Palmerston North 4474, New Zealand. c.conlon@massey.ac.nz.
Kathryn L BeckInstitute of Food Science and Technology-School of Food and Nutrition, Massey University, Palmerston North 4474, New Zealand. k.l.beck@massey.ac.nz.
Marlena C KrugerInstitute of Food Science and Technology-School of Food and Nutrition, Massey University, Palmerston North 4474, New Zealand. m.c.kruger@massey.ac.nz.
Pamela R von HurstInstitute of Food Science and Technology-School of Food and Nutrition, Massey University, Palmerston North 4474, New Zealand. P.R.vonHurst@massey.ac.nz.
Massey University · NZHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low vitamin D status in early development has been hypothesised as an environmental risk factor for Autism Spectrum Disorder (ASD), given the concurrent increase in the prevalence of these two conditions, and the association of vitamin D with many ASD-associated medical conditions. Identification of vitamin D-ASD factors may provide indications for primary and secondary prevention interventions. We systematically reviewed the literature for studies on vitamin D-ASD relationship, including potential mechanistic pathways. We identified seven specific areas, including: latitude, season of conception/birth, maternal migration/ethnicity, vitamin D status of mothers and ASD patients, and vitamin D intervention to prevent and treat ASD. Due to differences in the methodological procedures and inconsistent results, drawing conclusions from the first three areas is difficult. Using a more direct measure of vitamin D status--that is, serum 25(OH)D level during pregnancy or childhood--we found growing evidence for a relationship between vitamin D and ASD. These findings are supported by convincing evidence from experimental studies investigating the mechanistic pathways. However, with few primary and secondary prevention intervention trials, this relationship cannot be determined, unless randomised placebo-controlled trials of vitamin D as a preventive or disease-modifying measure in ASD patients are available.

Indexed as

Vitamin D DeficiencyAutism Spectrum DisorderFemaleHumansPregnancy25(OH)DASDAutism Spectrum DisorderbirthconceptionethnicityinterventionlatitudemigrationreviewseasonVitamin D

Identifiers

PMID27110819
PMCPMC4848704
OpenAlexW2337574406

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.