ArticleViruses2016
RNA-Sequencing Reveals the Progression of Phage-Host Interactions between φR1-37 and Yersinia enterocolitica.
Article in Viruses, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 89 citations in OpenAlex.
- Mechanism ofMicroorganisms · 2026Article
- Isolation, Characterization, and Evaluation of a Lytic Jumbo Phage Z90 AgainstAntibiotics (Basel, Switzerland) · 2025Article
- Global Transcriptomic Profiling Reveals Conserved and Phage-specific Responses to Phage Infection in Escherichia Coli.Microbial ecology · 2025Article
- Multi-omics characterization of a lytic phage targetingmSystems · 2025Article
- The Role of Bacteriophage-Derived Small RNA Molecules in Bacterial and Phage Interactions.Viruses · 2025Review
- Two novel polyvalent phages: a promising approach for cross-order pathogen control in aquaculture.Virology journal · 2025Article
- Phage reprogramming ofmBio · 2025Article
- Elucidation of molecular function of phage protein responsible for optimization of host cell lysis.BMC microbiology · 2024Article
- The Transcriptional Program ofViruses · 2024Article
- Transcriptional dynamics during Rhodococcus erythropolis infection with phage WC1.BMC microbiology · 2024Article
- Article
- Anaerobiosis, a neglected factor in phage-bacteria interactions.Applied and environmental microbiology · 2023Article
- Transcriptional Landscapes ofViruses · 2023Review
- Identification of over ten thousand candidate structured RNAs in viruses and phages.Computational and structural biotechnology journal · 2023Article
- Characterization and genomic study of EJP2, a novel jumbo phage targeting antimicrobial resistantFrontiers in microbiology · 2023Article
- An ensemble method for prediction of phage-based therapy against bacterial infections.Frontiers in microbiology · 2023Article
- Article
- Global Transcriptomic Analysis of Bacteriophage-Host Interactions between a Kayvirus Therapeutic Phage and Staphylococcus aureus.Microbiology spectrum · 2022Article
- Nutrient driven transcriptional changes during phage infection in an aquatic Gammaproteobacterium.Environmental microbiology · 2022Article
- A Novel Method to Create Efficient Phage Cocktails via Use of Phage-Resistant Bacteria.Applied and environmental microbiology · 2022Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the expanding interest in bacterial viruses (bacteriophages), insights into the intracellular development of bacteriophage and its impact on bacterial physiology are still scarce. Here we investigate during lytic infection the whole-genome transcription of the giant phage vB_YecM_φR1-37 (φR1-37) and its host, the gastroenteritis causing bacterium Yersinia enterocolitica. RNA sequencing reveals that the gene expression of φR1-37 does not follow a pattern typical observed in other lytic bacteriophages, as only selected genes could be classified as typically early, middle or late genes. The majority of the genes appear to be expressed constitutively throughout infection. Additionally, our study demonstrates that transcription occurs mainly from the positive strand, while the negative strand encodes only genes with low to medium expression levels. Interestingly, we also detected the presence of antisense RNA species, as well as one non-coding intragenic RNA species. Gene expression in the phage-infected cell is characterized by the broad replacement of host transcripts with phage transcripts. However, the host response in the late phase of infection was also characterized by up-regulation of several specific bacterial gene products known to be involved in stress response and membrane stability, including the Cpx pathway regulators, ATP-binding cassette (ABC) transporters, phage- and cold-shock proteins.
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