ReviewViruses2016
Constraints on the Genetic and Antigenic Variability of Measles Virus.
Review in Viruses, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 53 citations in OpenAlex.
- From sites to structure to serology: a roadmap for structure-aware molecular evolution of antigenically evolving viruses.Journal of virology · 2026Review
- Whole genome sequencing of measles viruses: the benefit for outbreak investigation, The Netherlands, 2013-2014.Virus genes · 2026Article
- Comprehensive mapping of human CD4Cell reports. Medicine · 2026Article
- Measles challenges: global resurgence and factors affecting eradication.Italian journal of pediatrics · 2026Review
- Three paradoxical paradigms of measles virus.PLoS pathogens · 2026Article
- Article
- A commentary on measles vaccine in the context of outbreaks: Viral evolution, waning immunity and public trust.Human vaccines & immunotherapeutics · 2025Review
- Occupational Transmission of Measles Despite COVID-19 Precautions.Pathogens (Basel, Switzerland) · 2025Article
- Structure of the measles virus ternary polymerase complex.Nature communications · 2025Article
- Eco-evolutionary dynamics of pathogen immune-escape: deriving a population-level phylodynamic curve.Journal of the Royal Society, Interface · 2025Article
- Impact of genotypic variability of measles virus T-cell epitopes on vaccine-induced T-cell immunity.NPJ vaccines · 2025Article
- What's going on with measles?Journal of virology · 2024Review
- Genomic tools for post-elimination measles molecular epidemiology using Canadian surveillance data from 2018-2020.Frontiers in microbiology · 2024Article
- Unwelcome return: analyzing the recent rise of measles cases in the United States.Proceedings (Baylor University. Medical Center) · 2024Review
- Genetic Characterization of the H Gene of MeV Strains (H1, B3, and D4) Recently Circulated in Iran for Improving the Molecular Measles Surveillance in the National Measles Lab.Iranian journal of public health · 2023Article
- Article
- Fitness selection of hyperfusogenic measles virus F proteins associated with neuropathogenic phenotypes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- An antigenic diversification threshold for falciparum malaria transmission at high endemicity.PLoS computational biology · 2021Article
- Molecular epidemiology of peste des petits ruminants virus emergence in critically endangered Mongolian saiga antelope and other wild ungulates.Virus evolution · 2021Article
- Challenges to Achieving Measles Elimination, Georgia, 2013-2018.Emerging infectious diseases · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Antigenic drift and genetic variation are significantly constrained in measles virus (MeV). Genetic stability of MeV is exceptionally high, both in the lab and in the field, and few regions of the genome allow for rapid genetic change. The regions of the genome that are more tolerant of mutations (i.e., the untranslated regions and certain domains within the N, C, V, P, and M proteins) indicate genetic plasticity or structural flexibility in the encoded proteins. Our analysis reveals that strong constraints in the envelope proteins (F and H) allow for a single serotype despite known antigenic differences among its 24 genotypes. This review describes some of the many variables that limit the evolutionary rate of MeV. The high genomic stability of MeV appears to be a shared property of the Paramyxovirinae, suggesting a common mechanism that biologically restricts the rate of mutation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.